Specific Preoperative Dynamic Contrast-enhanced MRI Semi-quantitative Markers Can Correlate With Vascularity in Specific Areas of the Glioblastoma Tissue and Predict Recurrence

Egyptian Medical Syndicate260 enrolled

Overview

Radiological Markers of vascularity as wash-in rate, washout rate, and capillary time to peak in different single tumour regions were extracted for all glioblastoma patients before being surgically resected from preoperative DCE-MRI. Tissue samples were obtained from different intratumoral regions and peritumoral oedema and evaluated for the vascular endothelial growth factor (VEGF)

Study Type

OBSERVATIONAL

Enrollment

260

Conditions

Glioblastoma

Interventions

Dynamic contrast-enhanced MRIOTHER

Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is the acquisition of sequential images during the passage of a contrast agent within a tissue of interest.

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with newly diagnosed glioblastoma with a maximum diameter from 3-5 cm as a single lesion identified by MRI. * The lesions should be surgically resected at the time of the presentation. Exclusion Criteria: N/A

Locations (1)

Department of Neurosurgery, Cairo University Faculty of Medicine

Cairo, Egypt

Outcomes

Primary Outcomes

Recurrence of tumor

Time frame: 2018-2021

Data from ClinicalTrials.gov

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