The first alarming symptom of a malignancy of the pancreas or periampullary tumor can be obstructive jaundice (OJ). Pancreato-duodenectomy (PD) combined with oncological treatment can provide long disease-free survival in resectable cases. The literature regarding the preoperative biliary drainage is controversial. The aim of this multicenter, prospective observational cohort study is to investigate the role of preoperative drainage, and to compare it with surgery alone.
Study Type
OBSERVATIONAL
Enrollment
353
Preoperative biliary drainage before surgical removal of the tumor
Pancreatic tumor resection without previous preoperative biliary drainage
rate of serious complications
rate of serious complications after preoperative biliary drainage and surgery 1. Pancreatitis 2. New onset of cholecystitis 3. Cholangitis 4. Perforation 5. Hemorrhage after endoscopic retrograde cholangiopancreatography (ERCP) 6. Related to stent 1. Occlusion 2. Need for exchange Related to surgery 7. Pancreas anastomosis leakage
Time frame: 120 days
rate of serious complications
rate of serious complications after preoperative biliary drainage and surgery defined as: 1. Pancreatitis 2. New onset of cholecystitis 3. Cholangitis 4. Perforation 5. Hemorrhage after endoscopic retrograde cholangiopancreatography (ERCP) 6. Related to stent 1. Occlusion 2. Need for exchange Related to surgery 7. Pancreas anastomosis leakage
Time frame: 120 days
Length of hospitalization
Length of hospitalization after biliary drainage and surgery
Time frame: 120 days
Mortality
Rate of mortality among groups
Time frame: 30 days
Mortality
Rate of mortality among the groups
Time frame: 120 days
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.