Intra-individual comparison of diagnostic performance of CEUS With perfluorobutane and sulfur hexafluoride for HCC in high-risk Individuals, and their role in the diagnostic algorithm of HCC.
The investigators would compare the diagnostic performance for HCC at high-risk individuals between both USG contrast agents.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
110
contrast enhanced ultrasound with perfluorobutane and sulfur hexafluoride
Participants underwent dynamic CT for hepatic lesion
Participants underwent liver MRI for hepatic lesion
Seoul National University Hospital
Seoul, Jongno-gu, South Korea
Diagnostic accuracy for HCC: non-inferiority test
The per-lesion diagnostic accuracy for HCC of CEUS with perfluorobutane and sulfur hexafluoride using the same diagnostic criteria (arterial phase hyperenehancement with mild and late (≥ 60 sec) washout).
Time frame: up to 3 months
Diagnostic performance of perfulorobutane enhanced USG using different definition of washout
Per-lesion sensitivity and specificity for diagnosing HCC using different time windows for assessing washout in PFB-US
Time frame: up to 3 months
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