Effect of Smoking Cessation on Tuberculosis Treatment Outcomes

Dow University of Health Sciences292 enrolled

Overview

This study was a Randomized Controlled Trial conducted at Ojha Institute of Chest Diseases, Dow University of Health Sciences, Karachi, among pulmonary tuberculosis patients

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

SINGLE

Enrollment

292

Conditions

Tuberculosis, Pulmonary

Interventions

BupropionDRUG

This group received Bupropion 150 mg twice daily for 10 weeks

Behavioural Change CommunicationBEHAVIORAL

This group will receive Behavioural Change Communication

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * pulmonary tuberculosis patients of age 18 years or above * registered under Directly Observed Treatment Short course (DOTS) at Ojha Institute of Chest Diseases * reported to have smoked 100 plus cigarettes in past and currently smoking cigarettes Exclusion Criteria: * Extra pulmonary tuberculosis * drug resistant tuberculosis * pregnancy * positive history of epilepsy

Locations (1)

Dow University of Health Sciences

Karachi, Sindh, Pakistan

Outcomes

Primary Outcomes

Percentage of patients completing anti-tuberculosis treatment

Among both smear positive and smear negative TB patients, successful completion of ATT will be labeled at the end of 6 months period if the patients has been compliant with ATT through six months period..

Time frame: six months

Secondary Outcomes

Percentage of participants achieving abstinence from smoking

Abstinence is defined as staying away from smoking and it will be assessed at week 1, week 4, week 12 and week 24 will be assessed in following two ways: i. Self-reported abstinence using questionnaire ii. Expired carbon monoxide (eCO) levels using Micro Smokerlyzer (Bedfont Scientific) of less than 7 ppm.

Time frame: six months

Data from ClinicalTrials.gov

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