Analgesic Effect of Quadratus Lumborum Block in Laparoscopic Hemicolectomy

Petrovsky National Research Centre of Surgery60 enrolled

Overview

Comparison of the effectiveness: Quadratus lumborum (QL) block by levobupivacaine with placebo.

All patients will receive standard anaesthesia using fentanyl, protocol, cisatracurium and sevoflurane. Prevention of nausea and vomiting is performing using Apfel score. All patients will receive post operative multimodal analgesia using paracetamol, ketoprofen, tramadol, and trimeperidine if numerical rating scale \> 3 The study assumes use of QL block by levobupivacaine.in comparison with placebo in order to demonstrate the effectiveness of QL block during the operation.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Enrollment

Conditions

Post Operative Pain

Interventions

Quadratus lumborum blockPROCEDURE

QL block will be used for perioperative anesthesia. The blockade will be performed bilaterally by levobupivacaine (20ml) at concentration 0.25%.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients who have undergone left-sided or right-sided laparoscopic hemicolectomy. * Patient's willingness and ability to sign an informed consent document Exclusion Criteria: * Allergy to local anesthetics * Chronic pain syndrome and associated opioid use. * Coagulopathy * Uncontrolled diabetes mellitus * Physical Status Classification System scale above 3 * Diseases associated with the pathology of the hypothalamus * Diseases associated with the pathology of the pituitary gland * Diseases associated with the pathology of the adrenal glands

Locations (1)

Petrovsky Research National Centre of Surgery ( Petrovsky NRCS)

Moscow, Russia

RECRUITING

Outcomes

Primary Outcomes

NRS (Numeric rating scale)

NRS scale 0-10, "no pain"; 10, "worst pain imaginable"

Time frame: two hours after surgery

Secondary Outcomes

The need for opioid analgesics during surgery

Time frame: on operations

The need for opioid analgesics for postoperative pain relief

Time frame: 72 hours after surgery

The need for antiemetic drugs to relieve postoperative nausea and vomiting

Time frame: 12 hours after the surgery

Occurrence of prolonged post-operative ileus

Time frame: first two weeks after surgery

Blood glucose level

Time frame: after induction into anesthesia, immediately after the end of the surgery, 12 hours after the surgery

The level of blood lactate

Time frame: after induction into anesthesia, immediately after the end of the surgery, 12 hours after the surgery

The level of cortisol in the blood

Time frame: after induction into anesthesia and immediately after the end of the surgery

The level of prolactin in the blood

Time frame: after induction into anesthesia and immediately after the end of the surgery.

Central Contacts

Evgenii Bespalov

CONTACT

+79854633843 evgenbespalovv@yandex.ru

Data from ClinicalTrials.gov

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