This is a prospective randomized controlled trial comparing high flow nasal cannula and buccal oxygenation as method of oxygenation during apnea in children.
This is a prospective randomized controlled trial comparing two oxygenation methods for prolongation of apnea time in children aged 0 to 10 years old. This study measures time for the pulse oximetry drop from 100% to 92% after oxygenation with 100% oxygen, applying high flow nasal cannula or buccal oxygen insufflation via an oral Ring-Adair-Elwyn endotracheal tube connected to oxygen.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Enrollment
38
Oxygen supplement via high flow nasal cannula at a rate of 2 liters/kg/min
Oxygen supplement intra-orally via oral Ring-Adair-Elwyn endotracheal tube connected to oxygen at a rate of 0.5 liters/kg/min
Seoul National University Hospital
Seoul, South Korea
Apnea success rate
Proportion of patients that succeed in prolongation of apnea time while maintaining pulse oximetry \> 92%
Time frame: From start of apnea to drop of pulse oximetry to 92%, up to 520 seconds
Apnea time
Time elapsed from start of apnea to resume of bag-mask ventilation
Time frame: From start of apnea to drop of pulse oximetry to 92%, up to 520 seconds
End-tidal carbon dioxide
End-tidal carbon dioxide partial pressure of first resumed breath after apnea
Time frame: After resuming of bag-mask ventilation, up to 30 seconds
Minimal pulse oximetry
Lowest value of pulse oximetry after resume of bag-mask ventilation
Time frame: After resuming of bag-mask ventilation, up to 60 seconds
Time to pulse oximetry of 100 percent
Time elapsed from resume of bag-mask ventilation to regain of 100 percent in the pulse oximetry value
Time frame: After resuming of bag-mask ventilation, up to 300 seconds
Electrocardiogram
Appearance of any arrhythmia or prolonged QT interval measured throughout the study
Time frame: From start of study to end of study, up to 20 min
Mean blood pressure
Mean non-invasive blood pressure measured throughout the study
Time frame: From start of study to end of study, up to 20 min
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Pulse oximetry
Pulse oximetry measured throughout the study
Time frame: From start of study to end of study, up to 20 min
Oxygen reserve index
Oxygen reserve index measured throughout the study
Time frame: From start of study to end of study, up to 20 min
Transcutaneous carbon dioxide
Transcutaneous carbon dioxide level measured throughout the study
Time frame: From start of study to end of study, up to 20 min
Heart rate
Heart rate measured throughout the study
Time frame: From start of study to end of study, up to 20 min