Body Composition Study in Critically Ill Patients-Extended to COVID-19

University of Malaya59 enrolled

Overview

Muscle loss (ultrasound quadricep muscle) and muscle strength (handgrip and knee extension strength) will be compared between COVID-19 and non COVID-19 critically ill patients.

Given the heightened inflammatory status among COVID-19 critically ill patients, we hypothesized that the rate of skeletal muscle loss is accelerated in this population, and this loss is even more pronounce than the general critically ill patients. We further hypothesized that the increased muscle loss will lead to worse functional outcome (lower muscle strength) in COVID-19 critically ill patients compared with age- and sex-matched non-COVID-19 critically ill patients, as it has been shown that quadriceps thickness is strongly correlated with functional status at ICU discharge. Furthermore, a recent systematic review and meta-analysis in survivors of coronavirus (severe acute respiratory syndrome, SARS or Middle-east respiratory syndrome, MERS, or COVID-19) also demonstrated reduced exercise capacity and quality of life at 6 months after hospitalization or ICU admission

Study Type

OBSERVATIONAL

Enrollment

Conditions

Critical Illness Covid19 Muscle Atrophy Muscle Strength

Interventions

No InterventionOTHER

This is an observational study and involved no intervention

Eligibility

Sex: ALLMin age: 18 YearsMax age: 90 Years

Medical Language ↔ Plain English

Inclusion Criteria: * ≥ 18 years old * Admitted into the ICU due to COVID-19 Exclusion Criteria: * Likely to transfer out from the ICU in 24 hours from screening * Likely to die in the next 7 days * Bedbound prior to hospital admission or bedbound in the hospital for \>10 days

Locations (1)

Faculty of Medicine, University of Malaya

Kuala Lumpur, Kuala Lumpur, Malaysia

Outcomes

Primary Outcomes

Rectus Femoris Thickness

Change in Rectus Femoris Thickness

Time frame: Change in Rectus Femoris Thickness at day 7 or ICU discharge or hospital discharge compared with baseline (Day 1 of ICU admission)

Rectus Femoris Cross-sectional Area

Change in Rectus Femoris Cross-sectional Area

Time frame: Change in Rectus Femoris Cross-sectional Area at day 7 or ICU discharge or hospital discharge compared with baseline (Day 1 of ICU admission)

Secondary Outcomes

Forearm Muscle Thickness

Change in Forearm Muscle Thickness

Time frame: Change in Forearm Muscle Thickness at day 7 or ICU discharge or hospital discharge compared with baseline (Day 1 of ICU admission)

Handgrip Strength

BIlateral Handgrip Strength

Time frame: Before Hospital Discharge

Knee Extension Strength

BIlateral Knee Extension Strength

Time frame: Before Hospital Discharge

Data from ClinicalTrials.gov

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