This study will investigate the role of sampling suspicious chest lymph nodes with a procedure called endobronchial ultrasound-guided transbronchial fine needle aspiration (EBUS-TFNA) or transesophageal ultrasound-guided fine needle aspiration (EUS-FNA) in patients planned to receive radical dose radiation. This study will use Stereotactic Ablative Radiotherapy (SABR) for treatment methods. SABR is a newer radiation treatment that delivers high-dose, precise radiation to small tumors and can be delivered more accurately than with older radiation treatment methods. It is considered a standard treatment for small lung cancers, and select cancers that have spread to the brain. The purpose of this study is to compare if the lymph node sampling procedure is valuable for determining the extend of nodal disease in metastatic Non-Small Cell Lung Cancer (NSCLC) compared to imaging alone.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
29
Chest lymph node sampling procedure by EBUS
Chest lymph node sampling procedure by EUS
London Health Sciences Centre - London Regional Cancer Program
London, Ontario, Canada
RECRUITINGSunnybrook Health Sciences Centre
Toronto, Ontario, Canada
RECRUITINGChanges to treatment intent and/or plan
Number of patients whose treatment is changed from stereotactic ablative radiotherapy (SABR) to conventional dose radiation, change in mediastinal radiation field, change from curative intent to palliative intent treatment
Time frame: 2 years
Determine the proportion of patients with occult mediastinal metastasis
Pre-staging treatment planning anticipated lymph nodes to be treated compared to post staging lymph nodes to be treated
Time frame: 2 years
Determine the sensitivity and specificity of radiologic staging of hilar/mediastinal lymph nodes
Nodal staging on imaging alone versus nodal staging after sampling
Time frame: 2 years
Identify the total number of lymph nodes sampled per procedure
Record the total number of lymph nodes sampled
Time frame: 2 years
Identify the nodal stations sampled
Record the nodal stations that were sampled
Time frame: 2 years
Determine the proportion of patients with complications of endoscopic procedure
Number of participants with complications versus number without
Time frame: 2 years
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