Dose Escalation and Expansion Study of CPO107 for Patients With Advanced CD20-positive Non-Hodgkins Lymphoma

Inclusion Criteria: The following key inclusion criteria apply to both Part A and Part B: * Diagnosis of CD20 positive NHL. CD20 assay to have been performed within 6 months prior to protocol entry. Eligible NHL subtypes include Diffuse Large B-Cell Lymphoma (DLBCL, not otherwise specified, NOS), Follicular Lymphoma, Chronic lymphocytic leukemia/small lymphocytic lymphoma, B cell prolymphocytic leukemia and Mantle cell lymphoma. * Patients with SLL must have received, or not be eligible for, BTK and BCL-2 inhibitor therapy. * Disease progression or relapse following at least two prior lines of conventional systemic therapy for advanced disease. Dosing regimen must have included a CD20 targeted therapy (for example, RCHOP). * A clinical indication for treatment must be present for patients with Follicular Lymphoma and Chronic/Small/Prolymphocytic/Mantle B-cell non-Hodgkin lymphoma. * Having at least one measurable target lesion present and documented by RECIST 1.1. * Adequate organ function, such as Renal function, Hepatic Function, Cardiovascular, Adequate hematological reserve. * Complete resolution of all prior toxicities from prior anticancer therapy, defined as having resolved to baseline or to common terminology criteria for adverse events (CTCAE) grade≤1, with the exception of alopecia, or to the levels dictated in the inclusion/exclusion criteria, and a washout period of 5 half-lives of prior small molecule systemic therapy. * Life expectancy \>12 weeks. * Age: Lower age limit of 18 years. * ECOG performance status 0 or 1 at screening. * Ability to understand the nature of this study, comply with protocol requirements, and give written informed consent. For minors, legal guardian willingness to give written informed consent with patient assent, where appropriate. * Patients of reproductive potential: All female study participants of reproductive potential must have a negative serum or urine pregnancy test performed within 48 hours before study entry. Exclusion Criteria: The following key exclusion criteria apply: * Patients with indolent Follicular Lymphoma or Chronic/Small/Prolymphocytic/Mantle B-cell non-Hodgkin lymphoma in need of immediate cytoreductive therapy are excluded, unless the patient has no remaining treatment choice with potential benefit. * Patient has participated in any investigational research study and is being screened for participation within a period of 5 half-lives, or 4 weeks of the last dose of the investigational therapy, whichever is longer. * Patients with history of severe hypersensitivity reactions to anti-CD20 treatment or any components of study drug formulation. * Presence or recent history within 6 months of arteritis or any systemic clotting disorder, thrombotic or thromboembolic events. * History or presence of autoimmune conditions; patients who have a medical condition that requires chronic systemic steroid therapy or requires any other form of immunosuppressive medication. * Patients with a marked baseline prolongation of QT/QTc interval (e.g., repeated demonstration of a QTc interval \>480 milliseconds (ms) (CTCAE grade 1) using Fredericia's QT correction formula. * Active or latent hepatitis B or active hepatitis C or any uncontrolled infection at screening; HIV positive test within 8 weeks of screening. * Serious active infection at the time of treatment, or another serious underlying medical condition that would impair the ability of the patient to receive protocol treatment. * Presence of other active cancers, or history of treatment for invasive cancer ≤3 years. * Patients who started erythropoietin or granulocyte colony-stimulating factor (G-CSF), pegfilgrastim, or filgrastim ≤4 weeks prior to the first dose of the study drug. * Psychological, familial, sociological, or geographical conditions that do not permit compliance with the protocol. * Active CNS disease involvement; CNS directed radiation must be completed \>8 weeks prior to CPO107 infusion. * Non-CNS site of radiation must be completed \>2 weeks prior to CPO107 infusion. * Pregnant or nursing (lactating) women * And others