Impact of Age and BMI on Liver Transplant Outcomes

University of Pittsburgh700 enrolled

Overview

Prospectively enrolled retrospective chart review and Liver Transplant database review to determine the modifiable and nonmodifiable risk factors specifically relating to Living Donor Liver Transplants. To observe the impact of age and BMI on graft outcomes and whether they impact the intraoperative management, post-operative length of stay, and complications.

There has been a great deal of research into the characteristics of the donor for organ transplant, with older donors and those with more comorbidities having worse function once the organ is implanted. There has not been a great deal of research in the United States about the recipient's characteristic including age and BMI and the effects on donor organ function. With increasingly expanded criteria for organ recipients especially in the field of living donor organs the investigators plan to show the impact of older age and increased BMI on newly transplanted organs.

Study Type

OBSERVATIONAL

Enrollment

700

Conditions

Liver Transplant; Complications Perioperative/Postoperative Complications

Interventions

CadavericPROCEDURE

Cadaveric Organ Transplant

Living DonorPROCEDURE

Living Donor Organ Transplant

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * All patients who received a liver transplant at UPMC- Montefiore Hospital Age\> 18 Exclusion Criteria: * Excludes Children (\<18 years old) as they do not receive their operation under the same protocols Lost to follow-up prior to 1 year Participation in alternate research protocol that significantly altered the care they received in the perioperative period that may make their inclusion skew results.

Locations (1)

UPMC Montefiore

Pittsburgh, Pennsylvania, United States

Outcomes

Primary Outcomes

Graft Function 30 day

How well does the organ function

Time frame: 30 day

Mortality

Mortality at 1 year

Time frame: 1 year

Graft Survival 1 year

Survival of Organ at 1 year

Time frame: 1 year

Secondary Outcomes

Perioperative Complications

Any complications in the perioperative period

Time frame: 30 day

Length of Stay- Total and ICU

How long after surgery before patient is discharged from ICU and from Hospital

Time frame: Up to 6 months

Duration of Intubation/Ventilation

Time from Surgery End to Extubation or no longer requiring ventilatory support

Time frame: Up to 6 months

Postoperative Complications

Complications in the postoperative period- Renal, Infectious Disease, Pulmonary, Cardiac, Transplant related, Reintubation, Reoperation

Time frame: Up to 6 months

Blood Transfusion

Amount of blood transfusion required intraoperatively

Time frame: Up to 2 days

Vasoactive Medication

Amount and Type of Vasoactive Medication used at procedure end

Data from ClinicalTrials.gov

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