Remdesivir Efficacy In Management Of COVID-19 Patients

Inclusion Criteria: Adult 18 -80 years old Must have laboratory confirmed COVID-19(A patient with laboratory confirmation (Positive RT-PCR) of COVID-19 infection, irrespective of clinical signs and symptoms according to Ain Shams University Hospitals Consensus Statement on Management of Adult COVID-19 Patients. Must have severe or immediately life-threatening COVID-19, * Severe disease is defined as: * Dyspnea, * Respiratory frequency ≥ 30/min, * Blood oxygen saturation ≤ 93%, * Partial pressure of arterial oxygen to fraction of inspired oxygen ratio \< 300, and/or lung infiltrates \> 50% within 24 to 48 hours * Life-threatening disease is defined as: * respiratory failure, * septic shock, and/or * multiple organ dysfunction or failure * Must provide informed consent by patient or his/her legal guardian or Professional Legal Representative Exclusion Criteria: * Mild to moderately affected COVID 19 confirmed patients. * pregnancy, lactation. * known hepatic failure. * Patient who is not likely to comply to study procedures. * Creatine clearance \<30 ml/min. * Elevated transaminases \> 5 fold ULN.