Breast Reconstruction in Previously Irradiated Breast

Humanitas Clinical and Research Center2,150 enrolled

Overview

For patients with breast cancer subject to a mastectomy, preserving the morphology of the breast with immediate reconstruction is a crucial aspect to preserve the quality of life. There are several types of breast reconstruction: prosthetic in one or two stages and autologous reconstruction. Adjuvant radiotherapy has shown an improvement of the overall survival and of the local control for patients with positive lymph nodes. As a consequence, plastic surgeons come into contact with more patients with a history of irradiation of their breasts than ever before. However, there are few studies with a significant number that evaluate the effect of pre-reconstruction radiotherapy on the three types of reconstruction. The aim of this study is to compare retrospectively these three types of reconstruction techniques to evaluate the impact of breast prior irradiation on the outcome of prosthetic reconstruction.

Study Type

OBSERVATIONAL

Enrollment

2,150

Conditions

Mammaplasty Radiotherapy; Complications Breast Implant; Complications Transplant Failure

Interventions

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients subjected to mastectomy and immediate reconstruction directly with prostheses, in two times and by autologue flaps (TRAM, Latissimus Dorsi Flap, DIEP and any other method) Exclusion Criteria: * Delayed prosthetic reconstruction

Outcomes

Primary Outcomes

Reconstruction failure

Complication rate (as hematoma, seroma, prosthetic exposure, skin and fat necrosis) that resulted in explant (prosthetic, expander or flap)

Time frame: 2 years

Secondary Outcomes

Reconstruction Complications

Rate of need for reintervention