Identifying Perceived Barriers and Facilitators Toward a Liver Transplantation Prehabilitation

University of Alabama at Birmingham114 enrolled

Overview

The purpose of this study is to formally identify patient and caregiver perceived needs, barriers, and facilitators to inform the development of a home-based multimodal prehabilitation program for potential LT candidates.

After being informed about the study and potential risks, all participants (patients and caregivers) giving written informed consent will be invited to participate in one of three research activities: interviews (n=10), nominal group technique meetings (n=64), or card-sorting and rating survey (n=40).

Study Type

OBSERVATIONAL

Enrollment

114

Conditions

Liver Transplant; Complications

Interventions

Prehabilitation interventionBEHAVIORAL

The investigators will identify participants' perceived important information to develop a prehabilitation intervention in this study. Prehabilitation intervention consisting of physical activities, nutrition, and stress management.

Caregiver interventionBEHAVIORAL

The investigators will provide caregivers with variety of educational resources for patients experiencing ESLD.

Eligibility

Sex: ALLMin age: 19 YearsMax age: 74 Years

Medical Language ↔ Plain English

Inclusion Criteria: Liver transplant (LT) candidates are: * Adult ESLD patients (age=19-74 years) who are assigned to the LT waitlist * English-speaking * No contraindication to moderate intensity physical activities * Physician clearance for participation in moderate intensity physical activities * No history of dementia or organic brain syndrome Caregivers: * Adult (age≥ 19 years) * English-speaking * Provide direct care to LT candidates Exclusion Criteria: * Inability to communicate verbally in English * Documentation of cognitive deficits

Locations (1)

University of Alabama at Birmingham

Birmingham, Alabama, United States

Outcomes

Primary Outcomes

Liver frailty index (LFI) score

Change from baseline in liver frailty index score at 3 months; the higher LFI scores indicate a higher degree of frailty. LFI\<3.2: robust, LFI=3.2-4.4: prefrail, LFI\>=4.5: Frail.

Time frame: From baseline through 3 months

Caregiver burden measured using Zarit Burden Interview short form (ZBI-12)

Change from baseline in the total ZBI-12 scores at 3 months. The total ZBI-12 score is the summation of 12 items, ranging from 0 to 48; the higher scores indicate higher burden (0-10:no to mild burden; 10-20: mild to moderate burden), and \>20: high burden.

Time frame: From baseline through 3 months

Data from ClinicalTrials.gov

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