To find superiority relationship between oral and intravenous administration of tranexamic acid on peroperative and postoperative blood loss, haemarthrosis prevalence and improvement functional prognosis in anterior cruciate ligament arthroscopy.
Tranexamic acid is an anti-fibrinolytic drug, recommended in total hip arthroplasty to reduce peroperative and postoperative hemorrhagic complications. The original character of our study lies in the serum dosage of tranexamic acid, allowing to correlate the primary objective (blood loss) with this one. The investigators will focus on the reduction of the risks associated with the administration of intravenous medicines, the economic aspect and the ease of use.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
QUADRUPLE
Enrollment
104
Oral administration of 2 grammes tranexamic acid 2 hours before skin incision and 2 grammes oral tranexamic acid 4 hours after first administration
Oral administration of lactose tablet (placebo)
CHU de Liège
Liège, Belgium
RECRUITINGAssessment of haemarthrosis
Postoperative (drainage) blood loss
Time frame: First 24 hours after surgery
Postoperative pain
Postoperative pain score on numeric ratio scale (NRS) from 0 (no pain) to 10 (worst pain)
Time frame: 24 hours after surgery
Postoperative pain
Postoperative pain score on numeric rating scale (NRS) from 0 (no pain) to 10 (worst pain)
Time frame: 72 hours after surgery
Postoperative pain
Postoperative pain score on numeric rating scale (NRS) from 0 (no pain) to 10 (worst pain)
Time frame: 7 days after surgery
Postoperative pain
Postoperative pain score on numeric rating scale (NRS) from 0 (no pain) to 10 (worst pain)
Time frame: 15 days after surgery
Clinical evaluation of functional recovery
Tegner activity score from 0 (no activity) to 10 (competitive sport)
Time frame: 1 days after surgery
Clinical evaluation of functional recovery
Tegner activity score from 0 (no activity) to 10 (competitive sport)
Time frame: 3 days after surgery
Clinical evaluation of functional recovery
Tegner activity score from 0 (no activity) to 10 (competitive sport)
Time frame: 7 days after surgery
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Clinical evaluation of functional recovery
Tegner activity score from 0 (no activity) to 10 (competitive sport)
Time frame: 15 days after surgery
Length of hospital stay
Total days of hospitalization
Time frame: First 30 days after surgery