Bioequivalence Study for Crizotinib Encapsulated Microsphere Formulation (eMS)

Inclusion Criteria: 1. Participants must be 18 to 55 years of age, inclusive, at the time of signing the informed consent document (ICD). 2. Male and female of non-childbearing potential participants who are overtly healthy as determined by medical evaluation including medical history, physical examination, and laboratory tests. 3. Participants who are willing and able to comply with all scheduled visits, treatment plan, laboratory tests, lifestyle considerations, and other study procedures. 4. Body Mass Index (BMI) of 17.5 to 30.5 kg/m2; and a total body weight \>50 kg (110 lb). 5. Capable of giving signed informed consent, which includes compliance with the requirements and restrictions listed in theICD and in this protocol. Exclusion Criteria: 1. Evidence or history of clinically significant hematological, renal, endocrine, pulmonary, gastrointestinal, cardiovascular, hepatic, psychiatric, neurological, or allergic disease. 2. Any condition possibly affecting crizotinib absorption (eg, gastrectomy, cholecystectomy, appendectomy). 3. History of HIV infection, chronic hepatitis B, or hepatitis C; positive testing for HIV, hepatitis B surface antigen (HBsAg), hepatitis B core antibody (HBcAb) or hepatitis C antibody (HCVAb). 4. Positive COVID-19 test. 5. History of sensitivity to heparin or heparin induced thrombocytopenia. 6. Known history of hypersensitivity to crizotinib or any components of the formulations. 7. Other medical or psychiatric condition: recent or active suicidal ideation/behavior, laboratory abnormality or conditions related to the COVID-19 pandemic that make the participant inappropriate. 8. Use of prescription or nonprescription drugs and dietary and herbal supplements within 7 days or 5 half-lives (whichever is longer) prior to the first dose of crizotinib. 9. Previous administration with an investigational drug within 30 days or 5 half-lives preceding the first dose of crizotinib (whichever is longer). 10. Positive urine drug test or cotinine test. 11. Supine BP \>=140 mm Hg (systolic) or \>=90 mm Hg (diastolic), following at least 5 minutes of supine rest. If BP \>=140 mm Hg (systolic) or \>=90 mm Hg (diastolic), BP should be repeated 2 more times. 12. Any clinically significant abnormality in 12-lead ECG, including QTcF \>450 msec, Computer-interpreted ECGs may be overread by a physician experienced in reading ECGs before excluding participants. 13. AST or ALT level \> (ULN); TBili level \>ULN; participants with a history of Gilbert's syndrome may have direct bilirubin \<= ULN; eGFR \<90 ml/min/1.73 m2 per CKD-EPI equation. 14. Male participants who are unwilling or unable to comply with the contraception requirement. 15. History of alcohol abuse or binge drinking and/or any other illicit drug use or dependence within 6 months of Screening. 16. Blood donation (excluding plasma donations) of approximately 1 pint (500 mL) or more within 60 days prior to dosing. 17. Participants who currently smoke. 18. Unwilling or unable to comply with the criteria in the Lifestyle Considerations section of this protocol. 19. Investigator site staff members or Pfizer employees directly involved in the conduct of the study, site staff otherwise supervised by the investigator, and their respective family members.