There is no consensus on antibiotic prophylaxis in dental implant applications, and its necessity is controversial. Current reports on antibiotic use are insufficient. Also, other than antibiotic prophylaxis, data that may affect the post-operative situation such as the patient's gender, age, smoking, duration of surgery, length of the operation field, flap design have not been evaluated comprehensively. This study aims to evaluate post-operative complications, implant success, and implant stability in 50 individuals: preoperative single dose of 2 g amoxicillin + clavulanic acid (25) and placebo (25).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
50
Insertion of not more than two dental implants at the same area
Per-os 2g amoxicillin+clavulanic acid will be administered one hour prior to the surgery
Per-os placebo (inert polysaccharide) will be administered one hour prior to the surgery
Biruni University
Istanbul, Turkey (Türkiye)
RECRUITINGBaseline implant stability / osseointegration
Periotest M
Time frame: Baseline
10th day implant stability / osseointegration
Periotest M
Time frame: 10th day
1st month implant stability / osseointegration
Periotest M
Time frame: 1st month
Final implant stability / osseointegration
Periotest M
Time frame: 3rd month
Radiographic bone loss
The distance of the bone crest to the implant shoulder
Time frame: 3rd month
Early healing index (Wachtel et al)
Complete flap closure (1), fine fibrin line (2), fibrin clot (3), partial necrosis (4), complete necrosis (5)
Time frame: 10th day
Early healing index (Wachtel et al)
Complete flap closure (1), fine fibrin line (2), fibrin clot (3), partial necrosis (4), complete necrosis (5)
Time frame: 1st month
Operation duration
Duration between the first incision and the last suture
Time frame: Baseline
Painkiller (0-3 days)
500 mg paracetamol, the count of the painkillers the subject used
Time frame: Baseline - 3rd day
Painkiller (3-10 days)
500 mg paracetamol, the count of the painkillers the subject used
Time frame: 3rd day - 10th day
Operation zone length
(mm) the crestal incision and vertical incision (if applied) length
Time frame: Baseline
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