Assessment of Seminal Levels of Cystatin C and Endoglin in Infertile Men With Varicocele

Benha University30 enrolled

Overview

Varicocele is a major contributor in male infertility. The improvement of sperm parameters after varicocelectomy supports this contribution. The pathophysiological mechanisms of varicocele-induced male infertility are still under investigation. Cystatin C (Cys C) and endoglin are secreted glycoproteins that recently linked to several cellular changes common in varicocele like apoptosis and autophagy.

Subinguinal varicocelectomy under general anesthesia and complete aseptic condition was done to infertile men with varicocele

Study Type

INTERVENTIONAL

Allocation

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Varicocele Infertility, Male

Interventions

VaricocelectomyPROCEDURE

Subinguinal varicocelectomy under general anesthesia and complete aseptic condition

Eligibility

Sex: MALEMin age: 18 YearsMax age: 39 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Infertile men * Varicocele * Poor sperm parameters Exclusion Criteria: * Men with systemic diseases * Infertile men due to other causes than varicocele

Locations (2)

Benha Faculty of Medecine

Banhā, Egypt

Benha Faculty of Medicine

Banhā, Egypt

Outcomes

Primary Outcomes

The Quality of Semen

According to WHO 2010 guidelines regarding semen analysis * Sperm concentration (to be more than 15 million sperm per milliliter). * Sperm motility (not less than 60% progressive motility). * Sperm morphology (not less than 6% normal morphology).

Time frame: 6 months

Data from ClinicalTrials.gov

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