Apnea testing is the final decisive examination in the strictly regulated process of brain death assessment. There is no standardized method found in the literature for apnea testing except for the inspection of possible spontaneous chest movements. In addition, the test itself lasts for several minutes leading to the collapse of the lungs. Electrical impedance tomography (EIT) is a non-invasive, real-time monitoring technique, which is suitable for detecting changes in lung volumes during ventilation. With its help, one can examine the spontaneous initiation of inspiration, the development of atelectasis and the reopening of collapsed regions by mechanical ventilation. Furthermore, the apnea test provides for analysing the effect of changes in pulmonary perfusion on impedance in the absence of noise generated by ventilation.
The aim of the study is to assess the eligibility of electrical impedance monitoring for the detection of possible spontaneous initiations of inspiration during apnea test in patients with suspected brain death. The study could contribute to the opening of new areas in the clinical use of the electrical impedance device. An additional aim is to observe the collapse and the reopening by recruitment manoeuvers of different pulmonary regions.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
10
Alveolar recruitment following the phase of apnea testing
University of Szeged
Szeged, Hungary
detection of spontaneous inspiration
Detection of absolute changes in impedance using EIT during apnea test, which may refer to spontaneous initiations of inspiration
Time frame: 20 minutes
Gas exchange
Change in arterial partial pressure of oxygen (PaO2) (mmHg) following alveolar recruitment performed after apnea testing
Time frame: 20 minutes
Dynamic compliance
Change in dynamic compliance (ml/cmH2O) following alveolar recruitment
Time frame: 20 minutes
End expiratory lung impedance
Change in end expiratory lung impedance (EELI) (%) following alveolar recruitment
Time frame: 20 minutes
Center of ventilation
Change in center of ventilation (%) following alveolar recruitment
Time frame: 20 minutes
Lung perfusion
Changes in lung perfusion during the apnea phase (%)
Time frame: 20 minutes
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.