This study is looking at the way insulin icodec stays and moves over time in the blood after injections in Chinese people with type 2 diabetes. Participants will get insulin icodec once a week for 6 weeks. The medicine will be injected under the skin of the thigh. There will also be a run-in period that will last between 1 week and 8 weeks with daily doses of insulin degludec before start on insulin icodec. The study will last for about 15 to 22 weeks. Participants will have about 17 visits with the study doctor including phone contact during your run-in period. Participants will have blood samples taken at the clinic visits. Several samples of participants blood will be taken for up to 48 hours after getting the first and the last dose of insulin icodec. Participants must be a Chinese person diagnosed with type 2 diabetes for at least 6 months and be on basal insulin treatment for at least 2 months before participating in the study. Women: Women cannot take part if pregnant, breast-feeding or plan to become pregnant during the study period
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
24
Participants will get insulin icodec once a week for 6 weeks. The medicine will be injected under the skin. The study will last for 15 to 22 weeks.
Novo Nordisk Investigational Site
Beijing, Beijing Municipality, China
Area under the serum insulin icodec concentration-time curve during one dosing interval at steady state
pmol\*h/L
Time frame: From 0 to 168 hours after trial product administration (Day 36)
Area under the serum insulin icodec concentration-time curve during one dosing interval at steady state divided by dose
(pmol\*h/L)/(U/kg)
Time frame: From 0 to 168 hours after trial product administration (Day 36)
Maximum observed serum insulin icodec concentration after the last dose
pmol/L
Time frame: From 0 to 168 hours after trial product administration (Day 36)
Maximum observed serum insulin icodec concentration after the last dose divided by dose
(pmol/L)/(U/kg)
Time frame: From 0 to 168 hours after trial product administration (Day 36)
Time to maximum observed serum insulin icodec concentration after the last dose
hours
Time frame: From 0 to 168 hours after trial product administration (Day 36)
Terminal half-life for insulin icodec at steady state
hours
Time frame: Terminal part of the serum insulin icodec concentration-time curve where the curve is well approximated by a straight line on logarithmic scale after last trial product administration (Day 36)
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