This prospective multicenter study will evaluate the efficacy of a real-time artificial intelligence system for detecting multiple ocular fundus lesions by ultra-widefield fundus imaging in real-world settings.
The ocular fundus can show signs of both ocular diseases (e.g., lattice degeneration, retinal detachment and glaucoma) and systemic diseases (e.g., hypertension, diabetes and leukemia). The routine fundus examination is conducive for early detection of these diseases. However, manual conducting fundus examination needs an experienced retina ophthalmologist, and is time-consuming and labor-intensive, which is difficult for its routine implementation on large scale. This study will develop an artificial intelligence system integrating with ultra-widefield fundus imaging to automatically screen for multiple ocular fundus lesions in real time and evaluate its performance in different real-world settings. The efficacy of the system will compare to the final diagnoses of each participant made by experienced ophthalmologists.
Study Type
OBSERVATIONAL
Enrollment
2,000
The participant only needs to take an ultra-widefield fundus image as usual.
Zhongshan Ophthalmic Center, Sun Yat-sen University
Guangzhou, Guangdong, China
RECRUITINGAccuracy
Performance of artificial intelligence system for detecting multiple ocular fundus lesions based on ultra-widefield fundus imaging.
Time frame: 8 months
Sensitivity
Performance of artificial intelligence system for detecting multiple ocular fundus lesions based on ultra-widefield fundus imaging.
Time frame: 8 months
Specificity
Performance of artificial intelligence system for detecting multiple ocular fundus lesions based on ultra-widefield fundus imaging.
Time frame: 8 months
Cohen's kappa coefficient
The comparison between the performacne of AI system and ophthalmologists of three degrees of expertise.
Time frame: 8 months
False-positive rate
Features of Misclassification
Time frame: 8 months
False-negative rate
Features of Misclassification
Time frame: 8 months
Data processing time of AI system
Data processing time of AI system.
Time frame: 8 months
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