Micromegaly and Discrepancy Between Growth Hormone and IGF1 at the Diagnosis and Follow-up of Acromegalic Patients

University Hospital, Montpellier250 enrolled

Overview

The diagnosis and the follow-up of acromegalic patients are based on the mesurement of Growth hormone (GH) and IGF1 rates. However, the literature described some cases of patient for whom the investigators observed a discrepancy between GH and IGF1 rates. Since the acromegaly is a rare disease and this phenomenon concerns about 30% of these patients, there is a lack of investigations about consequences that this discordance may induces. In this study, the investigators aimed at assessing if patients with discordance between GH and IGF1 rates present a different risk of recurrence and complications related to acromegaly, from patients with concordant results.

Study Type

OBSERVATIONAL

Enrollment

250

Conditions

Acromegaly

Eligibility

Sex: ALLMin age: 18 YearsMax age: 100 Years

Medical Language ↔ Plain English

Inclusion criteria: * Acromegaly followed up in one of the center (Montpellier, Nimes or Béziers hospital, independent endocrinologist) between 2010 and 2021 * Age over 18 years old * Measurement of GH and IGF1 rates at the last visit control available Exclusion criteria: * Lost to follow-up * Status about complications related to acromegaly unknown

Locations (1)

Uhmontpellier

Montpellier, France

Outcomes

Primary Outcomes

Occurrence of complications and/or recidivism related to acromegaly

The investigators check in the patient file if there is complications or pathology recidivism detected at the last full check-up of the disease, assessed by blood-control and complementary exams

Time frame: day 1

Secondary Outcomes

Disease's specificity

The investigators collected datas about disease's diagnosis (IRM characteristic, GH/IGF1 rates, clinical presentation) to evaluate if there is a different initial presentation between groups.