An Open-label, Exploratory Study to Investigate the Efficacy of BDNF Essentials® on Cognition

Inclusion Criteria: * Males and females 45 years of age and older * Waist circumference \< 102 cm (40 inches) in men and \< 88 cm (35 inches) in women * Female participant is not of child-bearing potential, defined as females who have undergone a sterilization procedure (e.g. hysterectomy, bilateral oophorectomy, bilateral tubal ligation, complete endometrial ablation) or have been post-menopausal for at least 1 year prior to enrollment Or, Females of child-bearing potential must have a negative baseline urine pregnancy test and agree to use a medically approved method of birth control for the duration of the study. All hormonal birth control must have been in use for a minimum of three months. Acceptable methods of birth control include: * Hormonal contraceptives including oral contraceptives, hormone birth control patch (Ortho Evra), vaginal contraceptive ring (NuvaRing), injectable contraceptives (Depo-Provera, Lunelle), or hormone implant (Norplant System) * Double-barrier method * Intrauterine devices * Non-heterosexual lifestyle or agrees to use contraception if planning on changing to heterosexual partner(s) * Vasectomy of partner at least 6 months prior to enrollment * A score of ≥ 24 on the Mini-Mental State Examination (MMSE 2) * Self-reported memory complaints as assessed by the revised Everyday Memory Questionnaire (EMQ) (with a score of ≥ 32) * Agrees to maintain current exercise routine, sleep and dietary patterns throughout the study * Agrees to avoid high caffeine consumption 24-hours prior to study appointments (examples include but not limited to no more than 2 cups of caffeinated coffee or tea) * Agrees to avoid alcohol consumption 24-hours prior to study appointments * Willingness to complete questionnaires, and diaries associated with the study and to complete all appointments * Provided voluntary, written, informed consent to participate in the study * Healthy as determined by medical history and laboratory results as assessed by the QI Exclusion Criteria: * Women who are pregnant, breast feeding, or planning to become pregnant during the study * Allergy, sensitivity, or intolerance to the investigational product's active or inactive ingredients * Dementia and/or cognitive decline or use of prescribed medications used to for dementia and/or cognitive decline (Section 6.3.1) * Prescribed medications for depression that may affect concentration, attention and performance as assessed by the QI (Section 6.3.1) * Current use of supplements used for cognition or mood support unless on a stable dose (Section 6.3.2) * History of epilepsy, brain injury or trauma as assessed by the QI * Self-reported confirmation of sleep disorder as assessed by the QI * Prescribed or over-the-counter medications or supplements used for sleep (Section 6.3.1 and 6.3.2) * Self reported colour-blindness * Prescribed use of antibiotics within 1 month of baseline (Section 6.3.1) * Prescribed use of anticoagulants/antiplatelets (Section 6.3.1) * Prescribed or chronic use of over-the-counter anti-inflammatory medications (Section 6.3.1 and 6.3.2) * Current use of supplements containing the ingredients in the IP unless willing to washout (Section 6.3.2) * Current employment that calls for rotating shift work or shift work that will disrupt normal circadian rhythm in the last 3 weeks * Travelled across 1 or more time zones in the last 3 weeks and/or is anticipating more travel during the study * Use of medical cannabinoid products * Current chronic use of cannabinoid products (\>8 times/month) and is unwilling to stop for the duration of the study beginning 1 week prior to baseline. History of chronic use and occasional use to be assessed by QI on a case-by-case basis * Use of tobacco, nicotine, or e-cigarette products within 12 weeks of baseline and during the study period * Self-reported alcohol or drug abuse within the last 12 months * Self-reported confirmation of HIV-, Hepatitis B- and/or C-positive diagnosis * Autoimmune disease including Type I diabetes or are immune compromised * Self-reported current or pre-existing thyroid condition. Treatment on a stable dose of medication for at least 3 months will be assessed by the QI * Clinically significant abnormal laboratory results at screening as assessed by the QI * Blood donation 30 days prior to enrollment, during the study, or a planned donation within 30 days of the last study appointment * Participation in other clinical research studies 30 days prior to enrollment will be assessed on a case-by-case basis by the QI * Individuals who are unable to give informed consent * Any other condition or lifestyle factor, that, in the opinion of the QI may adversely affect the participant's ability to complete the study or its measures or pose significant risk to the participant