Understanding Ketamine's Dissociative Effects (KD Study)

Phase 1RecruitingNCT04861051

Stanford University20 enrolled

Overview

The purpose of this study is to understand how ketamine brings about dissociative symptoms.

The goal of this proposed research is to record the effects of ketamine on brain activity to understand the changes that occur during dissociation in epilepsy patients with stereoEEG.

Study Type

INTERVENTIONAL

Allocation

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Epilepsy

Interventions

KetamineDRUG

Study participants will receive 0.5mg/kg of ketamine - one single infusion

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patient in Stanford Epilepsy Monitoring Unit * Age \>18 years old. Exclusion Criteria: * Lifetime psychotic or bipolar disorder * Inability to speak, read or understand English * Pregnant or nursing females * Prior adverse ketamine response

Locations (1)

Stanford University School of Medicine

Palo Alto, California, United States

RECRUITING

Outcomes

Primary Outcomes

Number of participants with dissociative events during ketamine infusion as assessed by CADSS (Clinician-Administered Dissociative State Scale)

The CADSS is an instrument for the measurement of dissociative symptoms. The CADSS comprises 23 subjective items and participant's responses are coded on a 5-point scale (0 = Not at all; 4 = Extreme). The higher the number on the CADSS, the more severe the symptoms.

Time frame: up to 1 week

Central Contacts

Arjay Cordero

CONTACT

650-580-9000 arjayc@stanford.edu

Data from ClinicalTrials.gov

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