The aim of this open label, randomized study is to compare the safety and efficacy of three different methods to handle coronary drug eluting stent (DES) in-stent restenosis (ISR). These are the: * Magic Touch - sirolimus coated balloon * Emperor - paclitaxel and dextran coated balloon * Xience - chromium-cobalt everolimus eluting stent
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
150
Intravascular devices will be assessed for the management of prior implanted drug eluting stent restenosis management.
Semmelweis University Heart and Vascular Center
Budapest, Budapest, Hungary
RECRUITINGUniversity of Szeged, Department of Invasive Cardiology
Szeged, Csongád-Csanád, Hungary
RECRUITINGOccurrence of new onset target vessel myocardial infarction
New onset myocardial infarction that affects the target vessel treated with either study device
Time frame: 6 months
Occurrence of target vessel revascularization of failure
The need for further revascularization affecting the target vessel treated with either study device, or the failure of the vessel treated by either study device.
Time frame: 6 months
Occurrence of target lesion revascularization
The need for further revascularization of the target lesion after treatment with either study device.
Time frame: 6 months
Percentage late lumen loss
Late lumen loss measured via qualitative coronary angiography in treated segment(s)
Time frame: 6 months
Percentage intraluminal gain after treatment
Intraluminal gain after assigned treatment measured via optical coherence tomography
Time frame: index procedure
Square millimetre intraluminal gain after treatment
Intraluminal gain after assigned treatment measured via optical coherence tomography
Time frame: index procedure
Percentage intraluminal gain after treatment
Intraluminal gain after assigned treatment measured via optical coherence tomography
Time frame: 6 months
Square millimeter intraluminal gain after treatment
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Intraluminal gain after assigned treatment measured via optical coherence tomography
Time frame: 6 months
Endothelium coverage in micrometers
Mean endothelium thickness of stent struts in micrometres measured via optical coherence tomography
Time frame: 6 months
Late lumen loss in square millimetres
Late lumen loss in square millimetres measured via optical coherence tomography
Time frame: 6 months