In this translational research study, Formalin-Fixed-Paraffin-Embedded (FFPE) tumor tissue blocks from patients with early-stage (II-III) colorectal cancer will be assessed for a comprehensive cancer gene panel from NIPD Genetics (https://www.nipd.com/) targeting regions in 37 clinically relevant cancer genes. The colorectal cancer panel includes an extended list of clinically relevant genes, designed to target clinically actionable and clinically significant mutations that will provide physicians with genetic information regarding a) prediction of the patient's response to targeted therapy, b) prognosis, that is, prediction of clinical outcome, c) diagnosis and molecular classification of colorectal cancer.
Study Type
OBSERVATIONAL
Enrollment
300
comprehensive cancer gene panel targeting regions in 37 clinically relevant cancer genes in FFPE tumor tissue blocks
Hellenic Cooperative Oncology Group
Athens, Greece
RECRUITINGassociation between gene mutational status and overall survival
the time from diagnosis to the date of death (from any cause). Alive patients and patients lost to follow-up will be censored at the date of last follow-up
Time frame: 24 months
association between gene mutational status and disease-free survival
the time from colorectal cancer diagnosis to the first date of documented disease progression, death or last contact, whichever occurs first
Time frame: 24 months
Descriptives
Association of any gene mutation tumor pathological stages.
Time frame: 24 months
Descriptives
Association of any gene mutation tumor budding.
Time frame: 24 months
Descriptives
Association of any gene mutation with microstatellite instability.
Time frame: 24 months
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