RESSURE-NIRS registry is designed to investigate clinical and pathophysiological characteristics of NIRS-derived lipid-rich plaque in patients with coronary artery disease. This is an on-going multi-center prospective registry in Japan.
NIRS imaging is an invasive intravascular imaging modality to quantitatively visualize lipid-rich atheroma in vivo. While NIRS-derived lipid-rich plaque has been shown to associate with cardiovascular events, there is limited clinical data about the association of this high-risk plaque with risk factors, medication use, prognosis and response of PCI. RESSURE-NIRS registry is an on-going multi-center prospective registry in Japan, which enroll subjects with coronary artery disease who received NIRS imaging to evaluate coronary atherosclerosis. The primary outcome is maximum 4-mm lipid core burden index at coronary lesions measured by NIRS imaging. Secondary major outcomes include entire lipid core burden index, plaque volume, plaque attenuation and echo-lucent area. The anticipated number of study subjects is 2000 cases.
Study Type
OBSERVATIONAL
Enrollment
2,000
Near-infrared spectroscopy is an intravascular imaging device to visualize lipid-rich plaque of coronary artery.
Miyazaki Medical Association Hospital
Miyazaki, Japan
RECRUITINGNational Cerebral & Cardiovascular Center
Suita, Japan
RECRUITINGMACE
major adverse cardiovascular events (=cardiac-cause death, non-fatal MI and clinically-driven non-restenotic coronary revascularization)
Time frame: at an average of 3 year
Coronary physiological characteristics at lipid-rich plaques
Identify and quantify coronary physiological findings (=fractional flow reserve and delta fractional flow reserve) for cardiovascular risk stratification of persons with lipid-rich plaques.
Time frame: Physiological measures are collected during the procedure: percutaneous coronary intervention
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