Effects of Breathing Patterns on Post-prandial Vascular Function

Texas State University21 enrolled

Overview

The purpose of this study is investigate the effects of two different breathing styles on postprandial vascular function and oxidative stress markers. Participants will complete 2 breathing conditions in random order.

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Healthy

Interventions

Normal physiologic rate breathingBEHAVIORAL

2-minute breathing exercises will be completed every 15 minutes.

Slow breathingBEHAVIORAL

2-minute breathing exercises will be completed every 15 minutes.

Eligibility

Sex: MALEMin age: 18 YearsMax age: 35 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: • Male participants ages 18-35 years Exclusion Criteria: * Infection within the previous 4 weeks * Renal disorders * Any cardiovascular disorders such as prior myocardial infarction, known coronary artery disease, personal history of stroke, heart failure, cardiac arrhythmias * Chronic obstructive pulmonary disease * Diabetes * Inflammatory bowel disease * HIV, rheumatoid arthritis, chronic or other inflammatory conditions * Currently taking steroids or other anti-inflammatory medications * Current use of nonsteroidal anti-inflammatory drugs * Smoking * Stage 2 hypertension or higher (systolic BP of 140 mm Hg or higher and/or diastolic BP of 90 mm Hg or higher) * Lactose intolerance

Locations (1)

Cardiovascular Physiology Laboratory-Texas State University

San Marcos, Texas, United States

Outcomes

Primary Outcomes

Change in flow-mediated dilation

Ultrasound-derived images of the brachial artery pre- and post-suprasystolic cuff inflation will yield flow-mediated dilation values. These are indices are endothelium-dependent vasodilation.

Time frame: At baseline and at again 1, 2, 4 hours post high-fat meal consumption

Changes in oxidative stress

Blood draws will be performed and samples will be processed and stored for future biochemical analysis of blood markers indicative of oxidative stress.

Time frame: Once at baseline and again at 1, 2, and 4 hours post high-fat meal consumption.

Data from ClinicalTrials.gov

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