Longitudinal prospective exploratory study on the evolution of dyspnea, in its sensory and affective dimensions, in patients followed for idiopathic pulmonary fibrosis (IPF), between inclusion and a 6-month evaluation
Dyspnea is a multidimensional experience involving a sensory component and an affective component. To better understand this symptom in IPF, this study will describe the different component of dyspnea and their evolution between inclusion and a 6-month evaluation in IPF patients. There is no strong correlation between the intensity of dyspnea and respiratory function impairments. Innovative techniques demonstrated abnormalities in ventilation variability and pulmonary compliance in patients with interstitial lung disease. These abnormalities could be more relevant to explain dyspnea. The objective of this work is also to assess the link between the different dimensions of dyspnea and respiratory functional parameters, ventilation variability and ventilatory mechanics measured by impulse oscillometry technique.
Study Type
OBSERVATIONAL
Enrollment
51
Hop Calmette Chu Lille
Lille, France
Evolution of the sensory and affective components of dyspnea
Description and changes in sensory (SQ) and affective (A2) scores of the Multidimensional Dyspnea Profile (MDP) questionnaire
Time frame: baseline, 6 months
Evolution of dyspnea during activities of daily living
Description and changes in San Diego Shortness of Breath Questionnaire (SOBQ) score
Time frame: baseline, 6 months
Association between the sensory and affective components of dyspnea and quality of life, anxiety symptoms, lung volumes, gas exchanges, ventilation variability, pulmonary compliance, pulmonary hypertension
Correlation between SQ and A2 scores of the MDP questionnaire and King's Brief Interstitial Lung Disease (K-BILD) questionnaire score, State Trait Anxiety Inventory (STAI-Y2) score, lung volumes measured by plethysmography, DLCO, PaO2, delta of desaturation during the 6-minute walk test, coefficient of variation of the tidal volume at rest, impulse oscillometry reactance, systolic pulmonary artery pressure assessed by cardiac ultrasound
Time frame: baseline, 6 months
Assess the prevalence of refractory dyspnea
Description of the prevalence of patients with visual anolog scale at rest \> 3 or mMRC scale \> 2
Time frame: baseline, 6 months
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.