Chronic pancreatitis (CP) is associated with recurrent intractable abdominal pain, pancreatic exocrine insufficiency and endocrine dysfunction. Very few studies had evaluated the quality of life in CP, and even a fewer have assessed the mental status in these patients. In the current study, we proposed to evaluate the the relationship between pain, quality of life and depression status in two large independent cohorts of patients with CP. We also proposed to evaluate the brain metabolites in the right and left anterior cingulate cortex, basal ganglia, hippocampus and prefrontal cortex using magnetic resonance spectroscopy. We further proposed to evaluate the pasta metabolites and look for associations with the mental state. Finally, we proposed to evaluate how CP related education of the patients could impact on their mental status and response to interventions on pain.
Study Type
OBSERVATIONAL
Enrollment
625
Patients in the second cohort were educated about their disease phenotype in a structured and personalised manner that included their disease course, symptoms, imaging, treatment option and possible long-term outcomes and prognosis. This was followed by answering all the queries of the patient and their caregivers. The patients were advised to visit the Pancreas clinic after 3-months for re-evaluation of the clinical, psychological and metabolic parameters.
Asian Institute of Gastroenterology
Hyderabad, Andhra Pradesh, India
Improvement in depression scores
Measured by the BDI II score
Time frame: 3 months
Improvement in Quality of life parameters
Measured by the EORTC-QLQc30 + PAN28
Time frame: 3 months
Change in brain metabolite profiles
Measured by using Magnetic resonance spectroscopy
Time frame: 3 months
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