Stem Cell Therapy for Chronic Kidney Disease

Inclusion Criteria: * Age 30-80 years. * Estimated glomerular filtration rate (eGFR) 25-55 ml/min/1.73m\^2 * Spot urine albumin:creatinine ≥30 mg/g unless on Renin-angiotensin-aldosterone system (RAAS) inhibition. * Ability to give informed consent. Exclusion Criteria: * Hemoglobin A1c greater than or equal to 11%.(in individuals with diabetes mellitus) * Anemia (hemoglobin less than 9g/dL) * Body weight greater than 150 kg or BMI greater than 50 * Uncontrolled hypertension: sustained systolic blood pressure (SBP) greater than 155 mmHg at screening exam (a maximum of 3 screening visits will be allowed for demonstration of blood pressure control) * Chronic hypotension: sustained SBP less than 85 mmHg at screening exam. * Glomerulonephritis not in partial or complete remission for 6 months (or estimated/measured proteinuria greater than 10 grams/day) * Active glomerulonephritis (glomerular disease) include: ANCA associated glomerulonephritis, post-infectious glomerulonephritis, lupus nephritis, amyloidosis, or other monoclonal gammopathy of renal significance. * Nephrotic syndrome defined as proteinuria greater than 3.5g per 24 hours, plus hypoalbuminemia (serum albumin less than or equal to 2.5g/L) and edema * Autosomal dominant or recessive polycystic kidney disease * Kidney failure requiring renal replacement therapy (hemodialysis, peritoneal dialysis, or kidney transplantation) * Active immunosuppression therapy (including prednisone greater than or equal to 10mg daily) * Kidney transplantation history * Solid organ transplantation history * Recent cardiovascular event (myocardial infarction, stroke, congestive heart failure) within 6 months or uncontrolled cardiac arrhythmias * Liver cirrhosis * Chronic obstructive pulmonary disease, asthma * History of blood clotting disorder (thromboembolism; pulmonary embolism, deep venous thrombosis) * Pregnancy * Active malignancy * Active infection * Active hepatitis B or C, or HIV infection * History of allergic reaction to cellular products (ie. blood transfusions, platelets) * Active tobacco use * Illicit drug use and excessive alcohol use presence of psychosocial issues (e.g., uncontrolled mental illness, unpredictable childcare or eldercare responsibilities, irregular/inflexible work schedule) that may interfere with the ability to complete all study procedures * Subjects anticipating prolonged travel or other physical restrictions that would prohibit return for scheduled study visits * Inability or unwilling to have magnetic resonance imaging (MRI) or computed tomography (CT) studies * Inability to give informed consent