Observational, longitudinal, prospective, prospective, comparative study of the effectiveness of triptans before and after onabotulintoxin A initiation in a single group of chronic migraine patients.
Hypothesis In patients with chronic migraine the efficacy of triptans, previously taken by the patient for the migraine attack, is better and more satisfactory after starting treatment with onabotulinumtoxinA. Objectives To analyze the efficacy and satisfaction of the triptan usually taken by the patient with chronic migraine before starting preventive treatment with onabotulinumtoxinA, at 4 months, after two sessions of Botox, and at 7 months of treatment, after three sessions of Botox. Sample size n=100 patients with chronic migraine in whom treatment with onabotulinumtoxinA is indicated. The indication for Botox treatment will be performed as usual and the patient will take his usual triptan if he has a migraine attack, so there is no therapeutic modification in this study that could involve any bioethical issue. All patients signed the informed consent and the study was approved by the Comitè d'Ètica de la Investigació amb Medicaments (CEIm) de l'Hospital de la Santa Creu i Sant Pau.
Study Type
OBSERVATIONAL
Enrollment
100
To compare the effectiveness of triptans before and after initiation of treatment with OnabotuliumtoxinA.
Headache and Neuralgia Unit. Neurology Department. Hospital Santa Creu i Sant Pau
Barcelona, Spain
RECRUITINGChange efficacy (Pain free at two hours )
Percentage of patients who are completely free of pain after two hours of ingestion of their usual triptan.
Time frame: From baseline to 4 months
Change efficacy (Pain free at two hours )
Percentage of patients who are completely free of pain after two hours of ingestion of their usual triptan.
Time frame: From baseline to 7 months
Satisfaction (Likert scale 1-5)
Satisfaction of treatment with triptans before and after treatment with OnabotulinumtoxinA
Time frame: From baseline to 4 months
Satisfaction (Likert scale 1-5)
Satisfaction of treatment with triptans before and after treatment with OnabotulinumtoxinA
Time frame: From baseline to 7 months
Pain free at one hour
Percentage of patients who are completely free of pain after one hour of ingestion of their usual triptan.
Time frame: 4 and 7 months
Sustained pain-free
Percentage of patients who achieve pain-free at two hours and do not require rescue medication within 24-48 hours.
Time frame: 4 and 7 months
Headache relapse
Percentage of patients experiencing recurrence of pain within 48 h on triptans with long half-life or 24 h on triptans with short half-life.
Time frame: 4 and 7 months
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