There is an urgent need to explore therapeutic options for SARS-CoV-2 in order to face the pandemic. The selected intervention was based on that zafirlukast will have dual effect; first it will block the virus replication through inhibiting the COVID19 helicase that is involved in virus replication and secondly by reducing the inflammation through antagonizing the leukotriene receptor. The purpose of this study is to evaluate the clinical efficacy and safety of Leukotriene receptor antagonist in the treatment of moderate cases of COVID-19 patients.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
66
Zafirlukast
Placebo
King Abdulaziz Medical city, MNGHA
Riyadh, Saudi Arabia
RECRUITINGTime to clinical improvement,
The time from symptoms resolved: No fever for 72 hours, no cough, no SOB or live discharge from the hospital, whichever came first.
Time frame: 28Day
Escalate therapy.
The requirement to escalate therapy.
Time frame: 28Day
PCR test
PCR test negative conversion rate at day 14
Time frame: Day14
Length of hospital stay.
Length of hospital stay.
Time frame: 28Day
Duration of fever
Duration of fever
Time frame: 28Day
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