Glycaemic Response and Insulinaemic Response for Nutralys S85 Plus and Whey Protein

N/ACompletedNCT04871971

Oxford Brookes University30 enrolled

Overview

A comparison of the glycaemic response and insulinaemic response to glucose, Nutralys S85 Plus pea protein and whey protein using a single-blind, randomised, repeat measure, crossover design trial.

A single-blind, randomised, repeat measure, crossover design trial will be used to study the glycaemic response and insulinaemic response following consumption of five products: one reference product (50 g available carbohydrate Glucose) and four test products (50 g available carbohydrate Glucose with 10 g NUTRALYS®S85 Plus pea protein, 50 g available carbohydrate Glucose with 20 g NUTRALYS®S85 Plus pea protein, 50 g available carbohydrate Glucose with 10 g Whey protein concentrate and 50 g available carbohydrate Glucose with 20 g Whey protein concentrate).

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

SINGLE

Enrollment

Conditions

Healthy

Interventions

10 g NUTRALYS®S85 Plus pea proteinDIETARY_SUPPLEMENT

To determine the glycaemic response and insulinaemic response to 50g Glucose + 10 g NUTRALYS®S85 Plus pea protein.

20 g NUTRALYS®S85 Plus pea proteinDIETARY_SUPPLEMENT

To determine the glycaemic response and insulinaemic response to 50g Glucose + 20 g NUTRALYS®S85 Plus pea protein.

10 g Whey protein concentrateDIETARY_SUPPLEMENT

To determine the glycaemic response and insulinaemic response to 50g Glucose + 10 g Whey protein concentrate.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Aged 18 to 60 years * Body mass index (BMI) less than 30kg/m2 Exclusion Criteria: * Pregnant or lactating * Fasting blood glucose value \> 6.1 mmol/l * Any known food allergy or intolerance * Medical condition(s) or medication(s) known to affect glucose regulation or appetite and/or which influence digestion and absorption of nutrients * Known history of diabetes mellitus or the use of antihyperglycaemic drugs or insulin to treat diabetes and related conditions * Major medical or surgical event requiring hospitalization within the preceding 3 months * Use of steroids, protease inhibitors or antipsychotics (all of which have major effects on glucose metabolism and body fat distribution) * Unable to comply with experimental procedures or did not follow GR testing safety guidelines.

Locations (1)

Oxford Brookes Centre for Nutrition and Health

Oxford, United Kingdom

Outcomes

Primary Outcomes

Change in blood glucose response from baseline for 3 hours

Change in postprandial blood glucose response from baseline was measured at 15 min, 30 min, 45 min, 1 hour, 1.5 hours, 2 hours, 2.5 hours and 3 hours

Time frame: 3 hours

Change in plasma insulin response from baseline for 3 hours

Change in postprandial plasma insulin response from baseline was measured at 15 min, 30 min, 45 min, 1 hour, 1.5 hours, 2 hours, 2.5 hours and 3 hours

Time frame: 3 hours

Area under the blood glucose concentration versus time curve

Area under the blood glucose concentration versus time curve was calculated by trapezoidal rule

Time frame: 3 hours

Area under the plasma insulin concentration versus time curve

Area under the plasma insulin concentration versus time curve was calculated by trapezoidal rule

Time frame: 3 hours

Peak blood glucose concentration (Cmax)

Peak blood glucose concentration (Cmax) after consumption of the test food

Time frame: 0-3 hours

Peak plasma insulin concentration (Cmax)

Peak plasma insulin concentration (Cmax) after consumption of the test food

Time frame: 0-3 hours

Time of blood glucose peak (Tmax)

Time of blood glucose peak after consumption of the test food

Time frame: 0-3 hours

Time of plasma insulin peak (Tmax)

Time of plasma insulin peak after consumption of the test food

Data from ClinicalTrials.gov

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