Hypotension Prediction Index in Patients Undergoing Liver Transplantation

Chang Gung Memorial Hospital60 enrolled

Overview

A prospective, open-label and single-center study to determine whether the use of Acumen Hypotension Prediction Index software predicts the occurrence of hypotension.

Study Type

INTERVENTIONAL

Allocation

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Intraoperative Hypotension

Interventions

Acumen HPI-enabled EV1000 screenDEVICE

Acumen HPI-enabled EV1000 screen record the incidence of intraoperative hypotension

Eligibility

Sex: ALLMin age: 20 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Written informed consent * Age ≥ 20 years; * Scheduled liver transplantation * Planned pressure monitoring with an arterial line; * General anesthesia Exclusion Criteria: * Contraindication for invasive blood pressure monitoring * End-staged renal disease * pre-operative MAP \<65 mmHg * Severe heart failure * Severe cardiac shunt * Severe aortic stenosis * Severe atrial fibrillation

Locations (1)

Chang Gung Memorial Hospital

Taoyuan City, Taiwan

RECRUITING

Outcomes

Primary Outcomes

Accurate hypotension prediction of EV1000 system

Analyze the actual incidence of hypotension after HPI alarm more than 85 within 15 min

Time frame: MAP measurements of each case were recorded every 20 s by the EV1000 system from induction to the end of surgery, assessed up to 1 day.

Incidence of intraoperative hypotension

Frequency, duration of intraoperative hypotension, which defined as MAP \< 65 mmHg at least 1 min

Time frame: MAP measurements of each case were recorded every 20 s by the EV1000 system from induction to the end of surgery, assessed up to 1 day

Severity of intraoperative hypotension

MAP measurements were recorded every 20 s by the EV1000 system from induction to Time-weighted average mean arterial pressure (TWA-MAP) \< 65 mmHg

Time frame: MAP measurements of each case were recorded every 20 s by the EV1000 system from induction to the end of surgery, assessed up to 1 day

Secondary Outcomes

Hospital stay and ICU stay

The incidence and severity of intraoperative hypotension correlate with patient's hospital stay and ICU stay

Time frame: Days from admission to discharge, assessed up to 1 month

Mortality after surgery

The incidence and severity of intraoperative hypotension correlate with patient's mortality

Time frame: Days from admission to discharge, assessed up to 1 month

Adverse effects

The incidence and severity of hypotension correlate with the adverse effects like acute liver failure, acute kidney injury and acute myocardial injury

Time frame: Days from admission to discharge, assessed up to 1 month

Central Contacts

BO HAN YEH

CONTACT

+886978989006 100311047@gms.tcu.edu.tw

Data from ClinicalTrials.gov

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