Significance of Immunohistochemical Expression of Survivin in Renal Cell Carcinoma

Sohag University40 enrolled

Overview

detection of Survivin expression in renal cell carcinoma and correlate this expression to tumor grade and stage.

renal cell carcinoma is the third most prevalent malignant tumor of the genitourinary system. deregulation of apoptosis is involved in carcinogenesis by abnormally prolonged cell survival, facilitating accumulations of multiple mutations and augment resistance to immune-surveillance. Survivin is a member of inhibitor of Apoptosis Protein family (IAPs). it play a role in cell cycle regulation by inhibiting apiptosis. Survivin is over-expressed in many human neoplasms.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Renal Cell Carcinoma

Interventions

sectioning and staining of renal neoplasms after nephrectomy operationDIAGNOSTIC_TEST

nephrectomy operations will be done to patients diagnosed as having renel tumors

Eligibility

Sex: ALLMin age: 30 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patients suffer from renal cell carcinomas Exclusion Criteria: * patients received pre-operative chemotherapy or radiotherapy. patients with insufficient clinical data.

Locations (1)

Maisa Hashem Mohammed

Sohag, Egypt

Outcomes

Primary Outcomes

expression of survivin in neoplastic and adjacent normal renal tissues

Survivin is highly expressed in neoplastic renal tissues compared to normal ones by immunohistochemical measures..

Time frame: april, 2021

Data from ClinicalTrials.gov

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