The purpose of this study is to understand the neural mechanisms that support real world spatial navigation in humans using deep brain recordings and stimulation during virtual reality (VR), augmented reality, and real world memory tasks. We will determine the cognitive (i.e., memory) and behavioral (i.e., body, head, eye position and movement) factors that modulate deep brain activity and the consequent effects of memory-enhancing deep brain stimulation.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Enrollment
70
Deep brain stimulation will be used
University of California Los Angeles
Los Angeles, California, United States
RECRUITINGSpatial memory
Spatial memory will be measured using virtual, augmented and real-world spatial navigation tasks where participants will be asked to navigate a previously learned rout as well as if they recognize objects (i.e. landmarks) that appeared along the route (photos of seen landmarks vs unseen landmarks).
Time frame: Throughout study completion, an average of 2-4 days per year
Memory performance change
Memory performance will be measured using excess path length, latency, and accuracy rate.
Time frame: Throughout study completion, an average of 2-4 days per year
Oscillatory activity change
Changes in theta, gamma, and theta-gamma coupling will be measured both in relation to changes in memory performance on trials with and without deep brain stimulation as well as in relation to body, head, and eye position in a virtual, augmented, or real-world environment.
Time frame: Throughout study completion, an average of 2-4 days per year
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