The Relationship Between Zonulin and Interleukin-8 Levels and Postoperative Delirium Development

Dr. Gokhan Vural73 enrolled

Overview

The relationship between zonulin and interleukin-8 levels and postoperative delirium development in patients who had femur fracture surgery under regional anesthesia

Patients who are over 65 years of age and scheduled for femur fixation surgery will be included in the study. Blood samples for zonulin and interleukin-8 levels will be taken at the day prior to the surgery. All patients will be evaluated by the Turkish version of the Delirium Rating Scale-Revised-98 (DRS-R-98) for delirium development at the postoperative 1., 2. and 3. days. Patients with a DRS-R-98 score of 11 points or higher will be included in the Group Delirium. And second blood samples for zonulin and interleukin-8 levels will be taken at the time of diagnosis. Postoperative pain scores of the patients will recorded by using a numerical rating scale (NRS).

Study Type

OBSERVATIONAL

Enrollment

Conditions

Postoperative Delirium

Interventions

Evaluation of Delirium developmentDIAGNOSTIC_TEST

Postoperative pain scores of the patients will recorded by using a numerical rating scale.

Eligibility

Sex: ALLMin age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patients over 65 years with mini mental state score \> 21, undergoing femur fixation surgery Exclusion Criteria: * anticholinergic drug use, known epilepsy, Parkinson, Alzheimer's disease, dementia, cognitive function disorder

Locations (1)

Muğla Sıtkı Koçman University

Muğla, Menteşe, Turkey (Türkiye)

Outcomes

Primary Outcomes

preoperative Zonulin

The relation between postoperative delirium development and preoperative blood zonulin levels. The correlation between them will be analyzed by statistical analysis.

Time frame: in the preoperative 24. hour

postoperative Zonulin

The relation between postoperative delirium development and postoperative blood zonulin levels The correlation between them will be analyzed by statistical analysis.

Time frame: At the postoperative 72. hour

Secondary Outcomes

preoperative Interleukin-8

The relation between postoperative delirium development and preoperative blood interleukin-8 levels. The correlation between them will be analyzed by statistical analysis.

Time frame: in the preoperative 24. hour

postoperative Interleukin-8

The relation between postoperative delirium development and postoperative blood interleukin-8 levels. The correlation between them will be analyzed by statistical analysis.

Time frame: At the postoperative 72. hour

Data from ClinicalTrials.gov

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