The purpose of this study is to explore the interplay among nervous-, musculoskeletal-, and psychological systems and how they impact toe-walking behavior, and vice versa. Sub-Project 1 is to analyze the feasibility of the developed virtual reality (VR) environment, in 10 TD and sCP children respectively. It is assess the effects of VR immersion on predefined static and dynamic stability parameters. Sub-Project 2: After adjustments have been made following Sub-Project 1 regarding the study procedure, technical factors or the parameters of interest etc., the optimized study procedure is implemented in Sub-Project 2 (20 to 25 TD will be included). Sub-Project 3: After adjustments have been made following Sub-Project 1 regarding the study procedure, technical factors or the parameters of interest etc., the optimized study procedure is implemented in Sub-Project3 (20 to 25 sCP will be included)
The interplay between the nervous-, musculoskeletal-, and psychological systems and their impact on resulting walking patterns are poorly understood. Children that toe-walk often show poorer levels of static and dynamic stability, leading to a lower quality of life compared to typically develop-ing children (TD). Current research suggests multifactorial adaptations in central and/or peripheral nervous as well as the musculoskeletal system contribute to and result from toe-walk-ing. The purpose of this study is to explore the interplay among nervous-, musculoskeletal-, and psychological systems and how they impact toe-walking behavior, and vice versa. The effect of psychological factors (via the use of a custom-designed virtual reality environment) on static vs. dynamic stability, motor control, coordination (indirect assessment of central nervous system function) as well as reflex control (Hoffmann-reflex, H-reflex, performance of peripheral nervous system) is investigated.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
46
The child stands barefoot on dual force platforms in two (CP: three) different conditions: barefoot and with shoes (CP: and with orthosis). Each condition is recorded three times each lasting for 30s, and 30s rest between them. Both conditions are recorded with and without wearing a headset. The order of conditions (within each Virtual Reality ("VR)-condition") is randomized. For each condition, the child rests in a comfortable position for 20s with the heels on the same level and arms hanging at their sides. Between both "VR-conditions", the child rests for 120 s.
The child walks at their normal walking speed on a 10-m walkway in two (CP: three) different conditions: barefoot and with shoes (CP: and with orthosis). For each condition, at least six error-free trials are recorded. Errors in data may occur due to hidden or lost markers during walking or software interruptions. Both conditions are recorded with and without wearing a headset. The order of conditions (within each "VR-condition") is randomized.
University Children's Hospital Basel, Neuroorthopedics I Human Locomotion Research
Basel, Switzerland
Static stability assessed by Center of Pressure (COP) shifts in anterior-posterior and mediolateral directions under each limb
COP shifts in anterior-posterior and mediolateral directions under each limb are assessed via the use of two force plates embedded in the floor (Kistler Instrumente AG, Winterthur, Switzerland, sample rate 1500 Hz) (mean value of three repetitions)
Time frame: one time assessment at baseline (complete baseline assessments up to 3 hours)
Static stability assessed by Visual Analogue Scale (VAS)
Self-perceived degree of safety during walking in the VR environment will be assessed using a Visual Analogue Scale (VAS) ranging from 0 ("feeling completely safe") to 10 ("feeling completely unsafe")
Time frame: one time assessment at baseline (complete baseline assessments up to 3 hours)
Static stability assessed by Ratio between H-reflex and M-wave amplitude
Ratio between H-reflex and M-wave amplitude, measured through soleus muscle in affected side of hemiplegic sCP and in none-dominant side for diplegic CP and TD (recruitment curve of the H-reflex and the M-wave of the Soleus elicited by stimulating the tibial nerve while standing)
Time frame: one time assessment at baseline (complete baseline assessments up to 3 hours)
Dynamic stability assessed by COP shifts in combination with base of support trajectory
COP shifts in combination with base of support trajectory assessed via the use of four force plates embedded in the floor (mean value of three repetitions)
Time frame: one time assessment at baseline (complete baseline assessments up to 3 hours)
Dynamic stability assessed by number of muscle synergies
Number of muscle synergies assessed via the use of a sixteen-channel surface electromyography system
Time frame: one time assessment at baseline (complete baseline assessments up to 3 hours)
Dynamic stability assessed by interlimb coordination
Interlimb coordination will be calculated by using kinematic data from lower and upper extremities
Time frame: one time assessment at baseline (complete baseline assessments up to 3 hours)
Dynamic stability assessed by Self-perceived degree of safety during walking in the VR environment using a Visual Analogue Scale (VAS)
Dynamic stability assessed by Self-perceived degree of safety during walking in the VR environment using a Visual Analogue Scale (VAS) ranging from 0 ("feeling completely safe") to 10 ("feeling completely unsafe")
Time frame: one time assessment at baseline (complete baseline assessments up to 3 hours)
Dynamic stability measurement assessed by kinematic data of upper & lower extremities (joint angles in degree)
Dynamic stability measurement assessed by kinematic data of upper \& lower extremities (joint angles in degree)
Time frame: one time assessment at baseline (complete baseline assessments up to 3 hours)
Dynamic stability measurement assessed by spatiotemporal parameters: walking speed (normalized to leg length) [m/(s*mm)]
Dynamic stability measurement assessed by spatiotemporal parameters: walking speed (normalized to leg length) \[m/(s\*mm)\]
Time frame: one time assessment at baseline (complete baseline assessments up to 3 hours)
Dynamic stability measurement assessed by spatiotemporal parameters: stride width [s]
Dynamic stability measurement assessed by spatiotemporal parameters: stride width \[s\]
Time frame: one time assessment at baseline (complete baseline assessments up to 3 hours)
Dynamic stability measurement assessed by spatiotemporal parameters: double support time [s]
Dynamic stability measurement assessed by spatiotemporal parameters: double support time \[s\]
Time frame: one time assessment at baseline (complete baseline assessments up to 3 hours)
Dynamic stability measurement assessed by spatiotemporal parameters: cadence [steps/min]
Dynamic stability measurement assessed by spatiotemporal parameters: cadence \[steps/min\]
Time frame: one time assessment at baseline (complete baseline assessments up to 3 hours)
Dynamic stability measurement assessed by spatiotemporal parameters: step length [m]
Dynamic stability measurement assessed by spatiotemporal parameters: step length \[m\]
Time frame: one time assessment at baseline (complete baseline assessments up to 3 hours)
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