The purpose of the study is to assess the optimal fraction of inspired oxygen (0.5 or 1) for extubation or removal of a supraglottic airway device after general anesthesia.
During pre-anesthesia visit, eligible patients receive oral and written information of the study and potential risks. In the operating room all patients giving a written informed consent will undergo at the end of surgery a screening to determine eligibility for study entry. Before emergence from general anesthesia, patients who meet the eligibility requirements will be randomized in a open label manner to receive a 0.5 or 1 FiO2.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
119
Ten minutes before emergence from general anesthesia, the amount of oxygen delivered from the mechanical ventilator called fractional inspired oxygen (FiO2) is set to 0.5 (50%)
Ten minutes before emergence from general anesthesia, the amount of oxygen delivered from the mechanical ventilator called fractional inspired oxygen (FiO2) is set to 1 (100%)
University Hospital, Caen
Caen, France
Decrease of oxygen saturation
Proportions of patients that present a decrease of 4 points of peripheral capillary oxygen saturation (SpO2) measured with pulse oximetry after extubation compared to their baseline room air SpO2
Time frame: Duration of stay in post-anesthesia care unit, approximately one hour
Duration of emergence
Elapsed Time between cessation of sedation and extubation (minutes)
Time frame: Up to one hour
Primary Outcome Timing
Elapsed time between extubation and decrease of oxygen saturation (minutes)
Time frame: Up to one hour
Number of risk factors
Number of factors associated with episodes of hypoxemia : bronchospasm, bronchial congestion (profuse secretions with the need to aspirate the patient several times), loss of upper airway muscle tonus (fall of the tongue).
Time frame: One hour
Majored decrease of oxygen saturation
Proportions of patients that present a decrease of 6 points of SpO2 after extubation compared to their baseline room air SpO2
Time frame: One hour
Corrective measures
Number of corrective measures (method and oxygen supply equipment used) after hypoxemia and proportion of success.
Time frame: One hour
PACU length of stay
Length of stay in post-anesthesia care unit
Time frame: One hour
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