Neuropsychological Indicators of SCD Progression

Centre Hospitalier Universitaire, Amiens80 enrolled

Overview

Some patients with subjective cognitive decline (SCD) progress to neurocognitive disorders (NCD), whereas others remain stable; however, the neuropsychological determinants of this progression have not been identified. The investigators objective was to examine baseline neuropsychological indicators that could discriminate between people in whom the SCD progressed to a mild or major NCD and people in whom the SCD remained stable. The investigators retrospectively included patients consulting for SCD at a university medical center's memory center (Amiens, France) and who had undergone three or more neuropsychological assessments at least 6 months apart. The relationship between domain-specific scores and the global cognitive score (GCS, as a function of final status (stable SCD vs. progression toward a mild or major NCD)) was examined using a generalized linear mixed model.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Biomarkers Cognitive Assessment Cognitive Decline Neurocognitive Disorders Neurodegenerative Diseases Subjective Cognitive Decline

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patients who had been referred to the memory center at Amiens University Medical Center (Amiens, France). * patients who had undergone three neuropsychological assessments at least 6 months apart, from 2005 * patients who met the criteria for SCD. Exclusion Criteria: * patients who didn't meet the criteria for SCD

Outcomes

Primary Outcomes

Variation of neuropsychological indicators (global congnitive score) between NCD et SCD patients

subjective cognitive decline (SCD) neurocognitive disorders (NCD) neuropsychological indicators could discriminate between people in whom SCD progressed to a mild or major NCD and people in whom SCD remained stable. A global cognitive score was created using all 5 tests : Alice Heim 4-I tests inductive reasoning ; Short-term verbal memory was assessed with a 20-word free-recall test; Two measures of verbal fluency were used: phonemic and semantic; Vocabulary was assessed using the Mill Hill Vocabulary test.

Time frame: one year