First-In-Human Study of GFB-024 in Healthy Overweight and Obese Participants, and Participants With Type 2 Diabetes

Inclusion Criteria: * 18 to 75 years of age at the time of signing informed consent. * Body mass index (BMI) between 25.0 and 40.0 kg/m2, inclusive, at Screening. * Female participants will be of non-childbearing potential. * Male participants will agree to use contraception while on study intervention and for at least 6 months after the last dose of study intervention. * SAD cohorts only: Participants must be in good health. * Repeat-dose cohort only: Type 2 diabetes mellitus (T2DM) treated with lifestyle modification or metformin, and in otherwise good health except for well-controlled common conditions associated with T2DM, such as hypertension and dyslipidemia. Exclusion Criteria: * History of, or treatment for, psychiatric illness, including anxiety or depression within 5 years of the Screening visit. * Participants with a history of attempted suicide or clinically significant suicidal ideation. * History of cardiovascular disease. * Blood pressure \>155 mmHg systolic or \>95 mmHg diastolic. * History of alcoholism or drug/chemical abuse within 2 years prior to Screening. * Alcohol consumption of \>21 units per week for males and \>14 units for females. One unit of alcohol equals 12 oz (360 mL) beer, 1.5 oz (45 mL) liquor, or 5 oz (150 mL) wine. * History of significant hypersensitivity, intolerance, or allergy to more than one class of drugs. * Positive hepatitis panel and/or positive human immunodeficiency virus test. Participants whose results are compatible with prior immunization may be included. * SAD cohorts only: Fasting glucose \>126 mg/dL.