The study will provide information on cognitive impairment and Health related quality of life in patients surviving 12 months after acute brain injury, generate a hypothesis of useful variables to predict cognitive impairment or low levels of HRQoL, and potentially inform interventions for the prevention and treatment of cognitive impairment following neuro-ICU stay.
The aim is to 1) measure the frequency and extent of cognitive impairment after acute brain injury at six and 12-months after neuro-Intensive care unit (ICU) admission 2) explore the association between cognitive impairment at six and 12 months after ICU admission with the following potential risk factors: duration of ICU delirium (days), duration of sepsis (days), duration of post traumatic amnesia (days) and the severity of brain injury (initial Glasgow Coma Scale , 3) describe Health related quality of life, functional disability and frailty at six and 12 after ICU admission and 4) explore the association between the functional disability, frailty and health-related quality of life at 12 months after ICU admission
Study Type
OBSERVATIONAL
no intervention
Change in Global cognitive function
measured by The Repeatable Battery for the Assessment of Neuropsychological Status, Overall score (mean 100; SD=15). Higher scores indicate better cognitive functioning.
Time frame: from baseline to 6 months after ICU admission
Change in Global cognitive function
measured by The Repeatable Battery for the Assessment of Neuropsychological Status, Overall score (mean 100; SD=15). Higher scores indicate better cognitive functioning.
Time frame: from baseline to 12 months after ICU admission
Change in Executive function
measured by Trail Making Test B, Score indicate time in seconds to complete task, the higher speed (less seconds) indicates higher executive function
Time frame: from baseline to 6 months after ICU admission
Change in Executive function
measured by Trail Making Test B, Score indicate time in seconds to complete task, the higher speed (less seconds) indicates higher executive function
Time frame: from baseline to 12 months after ICU admission
Change in Health related quality of life after brain injury
measured with a disease specific questionnaire:Quality of Life after Brain Injury overall scale (QOLIBRI-OS). Scores are from 0-100, the higher the score the more quality of life.
Time frame: from baseline to 6 months after ICU admission
Change in Health related quality of life after brain injury
measured with a disease specific questionnaire:Quality of Life after Brain Injury overall scale (QOLIBRI-OS). Scores are from 0-100, the higher the score the more quality of life.
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Time frame: from baseline to 12 months after ICU admission
Delirium
measured by Confusion measured by CAM-ICU or Intensive Care Delirium Screening Checklist (ICDSC).
Time frame: during the procedure (ICU stay) up to 30 days
Change in Disability after head injury/nontraumatic acute brain insults I
measured by Glasgow outcome scale extended (GOSE). Scores from 1 to 8, higher scores indicate less disability
Time frame: from baseline to 6 months after ICU admission
Change in Disability after head injury/nontraumatic acute brain insults I
measured by Glasgow outcome scale extended (GOSE). Scores from 1 to 8, higher scores indicate less disability
Time frame: from baseline to 12 months after ICU admission
Change in Disability after head injury/nontraumatic acute brain insults II
measured by Extended disability rating scale (DRS). Scores from 0 to 29, the higher the score the more disability
Time frame: from baseline to 6 months after ICU admission
Change in Disability after head injury/nontraumatic acute brain insults II
measured by Extended disability rating scale (DRS). Scores from 0 to 29, the higher the score the more disability
Time frame: from baseline to 12 months after ICU admission
Change in Frailty
measured by the Clinical Frailty Scale (CFS). Scale is from 1 to 9 ( the higher score the more frail).
Time frame: baseline to 6 months after ICU admission
Change in Frailty
measured by the Clinical Frailty Scale (CFS). Scale is from 1 to 9 ( the higher score the more frail).
Time frame: baseline to 12 months after ICU admission