The purpose of this study is to characterize the safety, tolerability, drug levels and drug effects of BMS-986196 in healthy participants. In addition, an evaluation of food and formulation effects on BMS-986196 absorption will be performed.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
102
Specified dose on specified days
Specified dose on specified days
Local Institution - 0002
Salt Lake City, Utah, United States
Incidence of Adverse Events (AEs)
Time frame: Up to 24 days
Severity of AEs
Time frame: Up to 24 days
Causality of AEs
Time frame: Up to 24 days
Incidence of Serious Adverse Events (SAEs)
Time frame: Up to 59 days
Severity of SAEs
Time frame: Up to 59 days
Causality of SAEs
Time frame: Up to 59 days
Incidence of clinically significant changes in vital signs: Body temperature
Time frame: Up to 24 days
Incidence of clinically significant changes in vital signs: Respiratory rate
Time frame: Up to 24 days
Incidence of clinically significant changes in vital signs: Blood pressure
Time frame: Up to 24 days
Incidence of clinically significant changes in vital signs: Heart rate
Time frame: Up to 24 days
Incidence of clinically significant changes in weight
Time frame: Up to 24 days
Incidence of clinically significant changes in physical examination
Time frame: Up to 24 days
Incidence of clinically significant changes in ECG parameters: QT interval
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Time frame: Up to 24 days
Incidence of clinically significant changes in ECG parameters: HR
Time frame: Up to 24 days
Incidence of clinically significant changes in clinical laboratory values: Hematology tests
Time frame: Up to 24 days
Incidence of clinically significant changes in clinical laboratory values: Clinical chemistry tests
Time frame: Up to 24 days
Incidence of clinically significant changes in clinical laboratory values: Coagulation tests
Time frame: Up to 24 days
Incidence of clinically significant changes in clinical laboratory values: Urinalysis tests
Time frame: Up to 24 days