A Study to Evaluate the Skin Irritation Potential of PBI-100 Topical Cream in Healthy Participants

Inclusion Criteria: * Healthy adult male and female volunteers between the ages of 18 and 70 years with Fitzpatrick types I, II, or III. * Must be willing to follow the study requirements and voluntarily give their informed consent. * Subjects must be able to read and follow study instructions in English. * Generally in good health as determined by the investigator, based on medical history interview. * Evidence of a personally signed and dated Informed Consent indicating that the subject has been informed of and understood all pertinent aspects of the trial. Exclusion Criteria: * Scars, moles, or other blemishes over the forearm, upper arm, or back that interfere with the study. * Sunburn within the last three weeks or use of tanning beds. * History of allergy or hypersensitivity to skin care or consumer products including fragrances, cosmetics, toiletries, or any kind of tape. * History of chronic or recurrent dermatological diseases, e.g., psoriasis, atopic eczema, chronic urticaria. * Subjects receiving systemic or topical drugs which can interfere with the development of an inflammatory response, e.g., steroids, immunosuppressive agents, or retinoids. * History of any significant systemic diseases e.g., cardiac, pulmonary, renal, hepatic, etc. that would impact subject's ability to complete the study. * Pregnancy or mothers who are breastfeeding or planning a pregnancy. * Other conditions considered by the Investigator as sound reasons for disqualification from enrollment into the study.