Oral mucosal ulcers can determine a real worsening of the quality of life. Conventional therapy usually lasts not less than 2-3 weeks, and carries a high risk of serious side effects; furthermore, ulcers often recur. The use of hyaluronic acid applied as an adhesive gel over the lesions seems to have potential in terms of efficacy and the avoidance of side effects. Of course, hyaluronic acid-based formulations show different effects and tolerability. In this retrospective observational study, the results obtained using a hyaluronic-acid based medical device applied for 14 days to counteract ulcers in adults will be reported.
Study Type
OBSERVATIONAL
Enrollment
49
Dosage: application of an even coat of 1mm thickness Frequency: 3 times/day (after main meals) Duration: 2 weeks
Dosage: application of an even coat of 1mm thickness Frequency: 3 times/day (after main meals) Duration: 2 weeks
University fo Urbino Carlo Bo
Urbino, Italy
Change in number of oral lesions
Change from baseline (Day 1) to Day 14 in the number of oral lesions observed in the two groups
Time frame: Day 1; Day 3; Day 6; Day 9; Day 12; Day 14
Change in size of oral lesions
Change from baseline (Day 1) to Day 14 in the size (mm) of oral lesions observed in the two groups
Time frame: Day 1; Day 3; Day 6; Day 9; Day 12; Day 14
Compliance to treatment
Number of daily treatments completed, timing of treatment application (hour of the day)
Time frame: From Day 1 to Day 14
Side effects to treatment
Dosage Record Treatment Emergent Symptom Scale (DOTES). It uses a Likert scale, going from 1 (no side effects) to 4 (severe side effects).
Time frame: From Day 1 to Day 14
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