Effect of Nitrous Oxide on EEG

Tampere University Hospital20 enrolled

Overview

Our recent preclinical observations suggest that monitoring of slow electroencephalogram (EEG) oscillations may be used to predict the efficacy of rapid-acting antidepressants such as ketamine or nitrous oxide. In this project we will carry out critical clinical research on healthy volunteers and study the effects of nitrous oxide on EEG. Results will be used for the design of clinical trials on depressed individuals. The project will be done in collaboration between neuroscientists at the University of Helsinki and clinicians at the Tampere University Hospital.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

DOUBLE

Enrollment

Conditions

Nitrous Oxide Electroencephalography Anesthetic, Inhalation

Interventions

Nitrous OxideDRUG

50% nitrous oxide

Eligibility

Sex: MALEMin age: 18 YearsMax age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. informed consent obtained 2. age between 18 - 40 3. male 4. body mass index 18 - 27 Exclusion Criteria: 1. Age \< 18 or \> 40 2. Alcohol Use Disorders Identification Test (AUDIT) \>6 points 3. Drug Abuse Screening Test 20 (DAST-20) \> 0 points 4. Beck Depression Inventory (BDI) \> 11 points 5. Symptom Check List 90 (SCL-90) over mean values of Finnish population in any dimensions of the SCL-90 or the global severity index 6. Any respiratory disorder including sleep apnea 7. Any heart illness 8. Epilepsy 9. Known vitamin B12 deficiency

Locations (1)

Tampere University Hospital

Tampere, Finland

Outcomes

Primary Outcomes

Slow wave activity

Delta wave in EEG

Time frame: During nitrous oxide administration

Slow wave activity

Delta wave in EEG

Time frame: Following 20 minutes after nitrous oxide administration

Secondary Outcomes

Self-reported psychiatric symptoms

Symptom Check List 90 (SCL-90) is a self-reported questionnaire measuring psychological stress. Results are normed, meaning that test scores can be compared to Finnish reference values. In this study we measure if there is an increase in self-reported psychiatric symptoms after nitrous oxide administration.