To evaluate the effectiveness and safety of camrelizumab combined with radiotherapy and chemotherapy for recurrent or metastatic cervical cancer
This study is a single-arm, single-center, open, prospective phase II clinical study, the main purpose of which is to evaluate the effectiveness and safety of camrelizumab combined with radiotherapy and chemotherapy for recurrent or metastatic cervical cancer.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
40
200mg/m2, iv, d1, Q3W, a total of 6 cycles
1.8-2.15Gy/time (radiotherapy started on the 8th day of camrelizumab treatment), a total of 28 times (5 times a week), a total of 50.4-60.2Gy.
260mg/m2, iv, d1, Q3W, a total of 6 cycles
TianjinCIH
Tianjin, Tianjin Municipality, China
RECRUITINGObjective response rate (ORR)
The objective remission rate refers to the proportion of patients whose tumors have shrunk to a certain amount and maintained for a certain period of time, including cases of complete remission and partial remission
Time frame: 2 year
Progression-free survival(PFS)
The period of time between when a patient with neoplastic disease receives treatment and when the disease progresses or death from any cause occurs
Time frame: 2 year
Overall survival(OS)
The time from the patient's confirmation of the disease to death due to any cause
Time frame: 2 year
Disease control rate(DCR)
Refers to the proportion of patients whose tumors have shrunk or stabilized for a certain period of time, including complete remission (CR), partial remission (PR) and stable (SD) cases
Time frame: 2 year
Adverse reaction rate
Harmful and unrelated reactions that occur when normal doses of drugs are used to prevent, diagnose, treat diseases or regulate physiological functions
Time frame: 2 year
Patient quality of life
Comprehensively evaluate the pros and cons of life by filling in the questionnaire
Time frame: 2 year
Chen
CONTACT
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80-120mg/m2, iv, d1-3, Q3W, a total of 6 cycles