The bioavailability of compound lisinopril tablets (specification: lisinopril 10mg / amlodipine 5mg) developed by Sichuan shangrui biomedical Co., Ltd. was compared with that of reference compound lisinopril tablets (specification: lisinopril 10mg / amlodipine 5mg) produced by Hungary Gedeon Richter Pharmaceutical Co., Ltd.The bioequivalence of single dose of test preparation and reference preparation was evaluated in heathy subjects under fasting and fed conditions.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
NONE
Enrollment
92
The subjects randomly received single oral administration of compound lisinopril tablet(Lisinopril 10mg/Levamlodipine besylate 5mg)
The subjects randomly received single oral administration of compound lisinopril tablet(Lisonorm®)
The Affiliated Hospital of Qingdao University
Qingdao, Shandong, China
Peak Plasma Concentration (Cmax)
Evaluate the Cmax of Lenopril and amlodipine for test preparation and reference preparation
Time frame: 90 days
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