Prevalence of dynamic hyperinflation and its relationship with functional exercise capacity will be evaluated in children with bronchiectasis.
Exercise or hyperpnea-induced air trapping is referred to as dynamic hyperinflation. In the presence of high resistance to expiratory flows and short expiratory times, the respiratory system is unable to return to its resting volume at the end of exhalation. The positive pressure within regions of hyperinflated lung raises the mean intrathoracic pressure and causes the inspiratory muscles to operate at a higher than resting lung volume. Thus, dynamic hyperinflation places the respiratory muscles at a considerable mechanical disadvantage and further impairs respiratory function. Dynamic hyperinflation is considered to be a key determinant of exercise capacity in patients with obstructive lung diseases. Although bronchiectasis is one of the obstructive lung diseases, the presence of dynamic hyperinflation in these patients has not been adequately investigated. Management guidelines of bronchiectasis state that imaging methods or pulmonary function tests alone is not sufficient to determine the disease burden and prognosis in these patients, so they recommend including detailed evaluation of exercise tolerance in the management of bronchiectasis. Aim of this study is to investigate the prevalence of dynamic hyperinflation and its relationship with functional exercise capacity in children with bronchiectasis.
Study Type
OBSERVATIONAL
Enrollment
40
"Spiropalm 6MWT" portable spirometry will be used during six-minute walk test for evaluation of dynamic hyperinflation and other related ventilatory parameters. The device will also be used as regular spirometry.
Functional exercise capacity of patients will be evaluated using six-minute walk test.
Handgrip strength and M. Quadriceps strength will be evaluated using hand-held dynamometer.
Ege University Faculty of Medicine, Department of Pediatrics, Division of Pediatric Pulmonology
Izmir, Turkey (Türkiye)
Dynamic hyperinflation
Dynamic hyperinflation will be defined as a decrease of \>100 mL in inspiratory capacity at the end of six-minute walk test determined by Spiropalm 6MWT device.
Time frame: At baseline
Six-minute walk distance
Distance walked in six minutes will be recorded. Test will be conducted according to the guideline of American Thoracic Society.
Time frame: At baseline
Minute ventilation
Maximum minute ventilation during six-minute walk test will be measured via Spiropalm 6MWT device.
Time frame: At baseline
Breathing reserve
Breathing reserve (BR) will be calculated as the difference between the maximal voluntary ventilation (MVV) and the maximum minute ventilation (VE) as a fraction of the MVV using Spiropalm 6MWT during six-minute walk test.
Time frame: At baseline
Forced Vital Capacity (FVC)
FVC will be measured before six-minute walk test according to the guideline of European Respiratory Society.
Time frame: At baseline
Forced Expiratory Volume in 1 second (FEV1)
FEV1 will be measured before six-minute walk test according to the guideline of European Respiratory Society.
Time frame: At baseline
Peak Expiratory Flow (PEF)
PEF will be measured before six-minute walk test according to the guideline of European Respiratory Society.
Time frame: At baseline
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
The Leicester Cough Questionnaire will be used for evaluating cough.
Handgrip strength
Handgrip strength will be measured using handgrip dynamometer.
Time frame: At baseline
M. Quadriceps strength
M. Quadriceps strength will be measured using hand-held dynamometer
Time frame: At baseline
Leicester Cough Questionnaire
Chronic cough will be evaluated using Leicester Cough Questionnaire. Questionnaire consists of 19 items covering physical, psychological and social domains with a 7 point likert response scale (range from 1 to 7). Higher score indicates better quality of life.
Time frame: At baseline