This is an open-label, randomized, crossover, single dose study. Two single doses of LC350189(tablet or capsule formulations) will be administered with a washout period of at least 4-day between the doses to investigate the relative bioavailability of LC350189 after administration via tablet formulation compared with capsule formulation and to evaluate basic systemic pharmacokinetic parameters of the tablet formulation compared to the capsule formulation of LC350189.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
23
Subject will receive an LC350189 Tablet as single dose on Day 1 or Day 5
Subject will receive an LC350189 Capsule as single dose on Day 1 or Day 5
PPD
Las Vegas, Nevada, United States
The relative bioavailability of LC350189 after administration via tablet formulation compared with capsule formulation by assessment of the area under the plasma concentration-time curve from zero to infinity for the tablet formulation capsule formation
Blood sample for determination of plasma concentration of LC350189 will be collected at pre-dose and 0.5,1,2,4,6,8,16,24,36,48, and 72 hours
Time frame: From baseline up to Day 8 (72 hours post on Day 5)
Incidence of Adverse events
Safety assessment
Time frame: From baseline up to Day 8
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